7ll7
From Proteopedia
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| - | ==== | + | ==[2]Catenane From MccJ25 Variant G12C G21C== |
<StructureSection load='7ll7' size='340' side='right'caption='[[7ll7]]' scene=''> | <StructureSection load='7ll7' size='340' side='right'caption='[[7ll7]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[7ll7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LL7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LL7 FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ll7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ll7 OCA], [https://pdbe.org/7ll7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ll7 RCSB], [https://www.ebi.ac.uk/pdbsum/7ll7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ll7 ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ll7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ll7 OCA], [https://pdbe.org/7ll7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ll7 RCSB], [https://www.ebi.ac.uk/pdbsum/7ll7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ll7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Mechanically interlocked molecules (MIMs), such as rotaxanes and catenanes, have captured the attention of chemists both from a synthetic perspective and because of their role as simple prototypes of molecular machines. Although examples exist in nature, most synthetic MIMs are made from artificial building blocks and assembled in organic solvents. The synthesis of MIMs from natural biomolecules remains highly challenging. Here, we report on a synthesis strategy for interlocked molecules solely made from peptides, that is, mechanically interlocked peptides (MIPs). Fully peptidic, cysteine-decorated building blocks were self-assembled in water to generate disulfide-bonded dynamic combinatorial libraries consisting of multiple different rotaxanes, catenanes and daisy chains as well as more exotic structures. Detailed NMR spectroscopy and mass spectrometry characterization of a [2]catenane comprising two peptide macrocycles revealed that this structure has rich conformational dynamics reminiscent of protein folding. Thus, MIPs can serve as a bridge between fully synthetic MIMs and those found in nature. | ||
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| + | Dynamic covalent self-assembly of mechanically interlocked molecules solely made from peptides.,Schroder HV, Zhang Y, Link AJ Nat Chem. 2021 Sep;13(9):850-857. doi: 10.1038/s41557-021-00770-7. Epub 2021 Aug , 23. PMID:34426684<ref>PMID:34426684</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7ll7" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Escherichia coli]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Link AJ]] |
| + | [[Category: Schroeder HV]] | ||
Current revision
[2]Catenane From MccJ25 Variant G12C G21C
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