Glucose 6-phosphate dehydrogenase

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*Glucose 6-phosphate dehydrogenase
*Glucose 6-phosphate dehydrogenase
 +
**[[7zve]] – hG6PD - human<br />
**[[1dpg]], [[1e7m]], [[1h93]], [[1h9b]] – LmG6PD (mutant) – ''Leuconostoc mesenteroides''<br />
**[[1dpg]], [[1e7m]], [[1h93]], [[1h9b]] – LmG6PD (mutant) – ''Leuconostoc mesenteroides''<br />
**[[3e15]] – G6PD – ''Plasmodium vivax''<br />
**[[3e15]] – G6PD – ''Plasmodium vivax''<br />
**[[3c8n]] – MtG6PD (mutant) – ''Mycobacterium tuberculosis''<br />
**[[3c8n]] – MtG6PD (mutant) – ''Mycobacterium tuberculosis''<br />
-
**[[4e9i]], [[6d23]] – TcG6PD – ''Trypanosoma cruzi''<br />
+
**[[6d23]] – TcG6PD – ''Trypanosoma cruzi''<br />
**[[4lgv]] – G6PD – ''Mycobacterium avium''<br />
**[[4lgv]] – G6PD – ''Mycobacterium avium''<br />
**[[5lxe]] – G6PD – ''Rhodococcus jostii''<br />
**[[5lxe]] – G6PD – ''Rhodococcus jostii''<br />
**[[7e6h]] – KlG6PD – ''Kluyveromyces lactis''<br />
**[[7e6h]] – KlG6PD – ''Kluyveromyces lactis''<br />
 +
**[[7zht]] – LdG6PD – ''Leishmania donovani''<br />
 +
**[[7xhp]] – ZmG6PD – ''Zymomonas mobilis''<br />
 +
**[[9emn]] – SyG6PD - ''Synechocystis'' – Cryo EM <br />
*Glucose 6-phosphate dehydrogenase complex
*Glucose 6-phosphate dehydrogenase complex
-
**[[1qki]], [[2bh9]], [[6e08]], [[6e0j]], [[6jyu]] – hG6PD + NADP - human<br />
+
**[[1qki]], [[2bh9]], [[6e08]], [[6e0j]], [[6jyu]], [[7zvd]] – hG6PD + NADP - human<br />
-
**[[6e07]] – hG6PD (mutant) + NADP <br />
+
**[[6e07]], [[6va0]], [[6va7]], [[6va8]], [[6va9]], [[6vaq]] – hG6PD (mutant) + NADP <br />
-
**[[5vg5]], [[6va0]], [[6va7]], [[6va8]], [[6va9]], [[6vaq]] – hG6PD (mutant) + NADP <br />
+
**[[2bhl]], [[5ukw]] – hG6PD (mutant) + G6P<br />
**[[2bhl]], [[5ukw]] – hG6PD (mutant) + G6P<br />
-
**[[4em5]], [[6d24]] – TcG6PD + G6P<br />
+
**[[6d24]] – TcG6PD + G6P<br />
**[[5aq1]] – TcG6PD + G6P + NADP<br />
**[[5aq1]] – TcG6PD + G6P + NADP<br />
**[[3b4y]] – MtG6PD (mutant) + coenzyme F420 <br />
**[[3b4y]] – MtG6PD (mutant) + coenzyme F420 <br />
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**[[1e7y]] – LmG6PD (mutant) + G6P + NADP<br />
**[[1e7y]] – LmG6PD (mutant) + G6P + NADP<br />
**[[7e6i]] – KlG6PD + G6P <br />
**[[7e6i]] – KlG6PD + G6P <br />
 +
**[[7xhl]] – ZmG6PD + NADP derivative<br />
 +
**[[7zhu]] – LdG6PD + NADP <br />
 +
**[[7zhx]], [[7zhy]] – LdG6PD (mutant) + NADP <br />
 +
**[[7zhv]] – LdG6PD + G6P <br />
 +
**[[7zhw]] – LdG6PD + G6P + NADP <br />
 +
**[[7zhz]] – LdG6PD (mutant) + G6P + NADP <br />
 +
**[[9emm]] – SyG6PD + OpcA – Cryo EM <br />
}}
}}

Current revision

Structure of glucose 6-phosphate dehydrogenase complex with glucose 6-phosphate and Ca+2 ion (green) (PDB code 1e77).

Drag the structure with the mouse to rotate

3D structures of glucose 6-phosphate dehydrogenase

Updated on 10-July-2025

References

  1. ↑ Tian WN, Braunstein LD, Pang J, Stuhlmeier KM, Xi QC, Tian X, Stanton RC. Importance of glucose-6-phosphate dehydrogenase activity for cell growth. J Biol Chem. 1998 Apr 24;273(17):10609-17. PMID:9553122
  2. ↑ Cappellini MD, Fiorelli G. Glucose-6-phosphate dehydrogenase deficiency. Lancet. 2008 Jan 5;371(9606):64-74. doi: 10.1016/S0140-6736(08)60073-2. PMID:18177777 doi:http://dx.doi.org/10.1016/S0140-6736(08)60073-2
  3. ↑ Cosgrove MS, Gover S, Naylor CE, Vandeputte-Rutten L, Adams MJ, Levy HR. An examination of the role of asp-177 in the His-Asp catalytic dyad of Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase: X-ray structure and pH dependence of kinetic parameters of the D177N mutant enzyme. Biochemistry. 2000 Dec 12;39(49):15002-11. PMID:11106478

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Michal Harel, Joel L. Sussman, Alexander Berchansky, Jaime Prilusky

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