1f0j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:09, 7 February 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1f0j.gif|left|200px]]
 
-
<!--
+
==CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B==
-
The line below this paragraph, containing "STRUCTURE_1f0j", creates the "Structure Box" on the page.
+
<StructureSection load='1f0j' size='340' side='right'caption='[[1f0j]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1f0j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F0J FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARS:ARSENIC'>ARS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
{{STRUCTURE_1f0j| PDB=1f0j | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f0j OCA], [https://pdbe.org/1f0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f0j RCSB], [https://www.ebi.ac.uk/pdbsum/1f0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f0j ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f0/1f0j_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f0j ConSurf].
 +
<div style="clear:both"></div>
-
'''CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B'''
+
==See Also==
-
 
+
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
-
 
+
== References ==
-
==Overview==
+
<references/>
-
Cyclic nucleotides are second messengers that are essential in vision, muscle contraction, neurotransmission, exocytosis, cell growth, and differentiation. These molecules are degraded by a family of enzymes known as phosphodiesterases, which serve a critical function by regulating the intracellular concentration of cyclic nucleotides. We have determined the three-dimensional structure of the catalytic domain of phosphodiesterase 4B2B to 1.77 angstrom resolution. The active site has been identified and contains a cluster of two metal atoms. The structure suggests the mechanism of action and basis for specificity and will provide a framework for structure-assisted drug design for members of the phosphodiesterase family.
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
1F0J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F0J OCA].
+
-
 
+
-
==Reference==
+
-
Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity., Xu RX, Hassell AM, Vanderwall D, Lambert MH, Holmes WD, Luther MA, Rocque WJ, Milburn MV, Zhao Y, Ke H, Nolte RT, Science. 2000 Jun 9;288(5472):1822-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10846163 10846163]
+
-
[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Hassell, A M.]]
+
[[Category: Hassell AM]]
-
[[Category: Holmes, W D.]]
+
[[Category: Holmes WD]]
-
[[Category: Ke, H.]]
+
[[Category: Ke H]]
-
[[Category: Lambert, M H.]]
+
[[Category: Lambert MH]]
-
[[Category: Luther, M A.]]
+
[[Category: Luther MA]]
-
[[Category: Milburn, M V.]]
+
[[Category: Milburn MV]]
-
[[Category: Nolte, R T.]]
+
[[Category: Nolte RT]]
-
[[Category: Rocque, W J.]]
+
[[Category: Rocque WJ]]
-
[[Category: Vanderwall, D.]]
+
[[Category: Vanderwall D]]
-
[[Category: Xu, R X.]]
+
[[Category: Xu RX]]
-
[[Category: Zhao, Y.]]
+
[[Category: Zhao Y]]
-
[[Category: Pde phosphodiesterase]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:44:44 2008''
+

Current revision

CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B

PDB ID 1f0j

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1f0j"
Personal tools