7aeh

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<StructureSection load='7aeh' size='340' side='right'caption='[[7aeh]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
<StructureSection load='7aeh' size='340' side='right'caption='[[7aeh]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7aeh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/2019-ncov 2019-ncov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AEH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AEH FirstGlance]. <br>
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AEH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AEH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=R8H:(2~{R})-5-oxidanylidene-~{N}-[(2~{R},3~{S})-3-oxidanyl-4-oxidanylidene-1-phenyl-4-(pyridin-2-ylmethylamino)butan-2-yl]-1-(phenylmethyl)pyrrolidine-2-carboxamide'>R8H</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">orf1ab ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2697049 2019-nCoV])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=R8H:(2~{R})-5-oxidanylidene-~{N}-[(2~{R},3~{S})-3-oxidanyl-4-oxidanylidene-1-phenyl-4-(pyridin-2-ylmethylamino)butan-2-yl]-1-(phenylmethyl)pyrrolidine-2-carboxamide'>R8H</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7aeh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aeh OCA], [https://pdbe.org/7aeh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7aeh RCSB], [https://www.ebi.ac.uk/pdbsum/7aeh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7aeh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7aeh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aeh OCA], [https://pdbe.org/7aeh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7aeh RCSB], [https://www.ebi.ac.uk/pdbsum/7aeh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7aeh ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
 
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[[https://www.uniprot.org/uniprot/A0A6B9VNL0_SARS2 A0A6B9VNL0_SARS2]] Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.[ARBA:ARBA00002182] Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.[ARBA:ARBA00003443] May participate in viral replication by acting as a ssRNA-binding protein.[ARBA:ARBA00002012] May play a role in the modulation of host cell survival signaling pathway by interacting with host PHB and PHB2. Indeed, these two proteins play a role in maintaining the functional integrity of the mitochondria and protecting cells from various stresses.[ARBA:ARBA00003115] Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16. Therefore plays an essential role in viral mRNAs cap methylation which is essential to evade immune system.[ARBA:ARBA00002840] Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.[ARBA:ARBA00002798] Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwinding activities with 5' to 3' polarity. Activity of helicase is dependent on magnesium.[ARBA:ARBA00002960] Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonuclease and nsp16 2'-O-methyltransferase activities. Therefore plays an essential role in viral mRNAs cap methylation.[ARBA:ARBA00002697] Responsible for replication and transcription of the viral RNA genome.[ARBA:ARBA00003927]
 
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 2019-ncov]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Brewitz, L]]
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[[Category: Brewitz L]]
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[[Category: Collette, A]]
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[[Category: Collette A]]
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[[Category: Collins, P]]
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[[Category: Collins P]]
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[[Category: Delft, F von]]
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[[Category: Douangamath A]]
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[[Category: Douangamath, A]]
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[[Category: Fearon D]]
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[[Category: Fearon, D]]
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[[Category: Hallet D]]
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[[Category: Hallet, D]]
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[[Category: Hopkins AL]]
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[[Category: Hopkins, A L]]
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[[Category: Hull H]]
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[[Category: Hull, H]]
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[[Category: Lukacik P]]
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[[Category: Lukacik, P]]
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[[Category: Malla TR]]
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[[Category: Malla, T R]]
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[[Category: Navratilova I]]
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[[Category: Navratilova, I]]
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[[Category: Nugen T]]
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[[Category: Nugen, T]]
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[[Category: Owen CD]]
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[[Category: Owen, C D]]
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[[Category: Radoux C]]
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[[Category: Radoux, C]]
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[[Category: Redhead MA]]
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[[Category: Redhead, M A]]
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[[Category: Robinson C]]
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[[Category: Robinson, C]]
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[[Category: Schofield CJ]]
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[[Category: Schofield, C J]]
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[[Category: Strain-Damerell C]]
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[[Category: Strain-Damerell, C]]
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[[Category: Stuart DI]]
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[[Category: Stuart, D I]]
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[[Category: Tumber A]]
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[[Category: Tumber, A]]
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[[Category: Walsh MA]]
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[[Category: Walsh, M A]]
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[[Category: Von Delft F]]
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[[Category: Covid-19]]
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[[Category: Hydrolase]]
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[[Category: Inhibitor]]
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[[Category: Protease]]
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Current revision

SARS-CoV-2 main protease in a covalent complex with a pyridine derivative of ABT-957, compound 1

PDB ID 7aeh

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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