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1i7e

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Current revision (06:23, 9 August 2023) (edit) (undo)
 
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<StructureSection load='1i7e' size='340' side='right'caption='[[1i7e]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='1i7e' size='340' side='right'caption='[[1i7e]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1i7e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I7E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1i7e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I7E FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IBS:L-ALPHA-GLYCEROPHOSPHO-D-MYO-INOSITOL-4,5-BIS-PHOSPHATE'>IBS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1c8z|1c8z]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IBS:L-ALPHA-GLYCEROPHOSPHO-D-MYO-INOSITOL-4,5-BIS-PHOSPHATE'>IBS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i7e OCA], [https://pdbe.org/1i7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i7e RCSB], [https://www.ebi.ac.uk/pdbsum/1i7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i7e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i7e OCA], [https://pdbe.org/1i7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i7e RCSB], [https://www.ebi.ac.uk/pdbsum/1i7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i7e ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/TUB_MOUSE TUB_MOUSE]] Note=Defects in Tub are the cause of maturity-onset obesity, insulin resistance and sensory deficits.
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[https://www.uniprot.org/uniprot/TUB_MOUSE TUB_MOUSE] Note=Defects in Tub are the cause of maturity-onset obesity, insulin resistance and sensory deficits.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TUB_MOUSE TUB_MOUSE]] Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight. Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages (By similarity).<ref>PMID:10591637</ref> <ref>PMID:11375483</ref>
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[https://www.uniprot.org/uniprot/TUB_MOUSE TUB_MOUSE] Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight. Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages (By similarity).<ref>PMID:10591637</ref> <ref>PMID:11375483</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Baird, C L]]
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[[Category: Baird CL]]
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[[Category: Boggon, T J]]
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[[Category: Boggon TJ]]
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[[Category: Santagata, S]]
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[[Category: Santagata S]]
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[[Category: Shan, W S]]
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[[Category: Shan WS]]
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[[Category: Shapiro, L]]
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[[Category: Shapiro L]]
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[[Category: Signaling protein]]
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[[Category: Tubby filled-barrel beta-barrel filled-beta-roll 12-stranded-beta-barrel helix-filled-barrel obesity blindness deafness phosphoinositide phosphatidylinositol]]
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Current revision

C-Terminal Domain Of Mouse Brain Tubby Protein bound to Phosphatidylinositol 4,5-bis-phosphate

PDB ID 1i7e

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