1f1m

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[[Image:1f1m.gif|left|200px]]
 
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==CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN C (OSPC)==
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The line below this paragraph, containing "STRUCTURE_1f1m", creates the "Structure Box" on the page.
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<StructureSection load='1f1m' size='340' side='right'caption='[[1f1m]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1f1m]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi Borreliella burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F1M FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1f1m| PDB=1f1m | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f1m OCA], [https://pdbe.org/1f1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f1m RCSB], [https://www.ebi.ac.uk/pdbsum/1f1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f1m ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9AGB1_BORBG Q9AGB1_BORBG]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/1f1m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1f1m ConSurf].
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<div style="clear:both"></div>
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'''CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN C (OSPC)'''
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==See Also==
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*[[Outer surface protein|Outer surface protein]]
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__TOC__
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==Overview==
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</StructureSection>
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Outer surface protein C (OspC) is a major antigen on the surface of the Lyme disease spirochete, Borrelia burgdorferi, when it is being transmitted to humans. Crystal structures of OspC have been determined for strains HB19 and B31 to 1.8 and 2.5 A resolution, respectively. The three-dimensional structure is predominantly helical. This is in contrast to the structure of OspA, a major surface protein mainly present when spirochetes are residing in the midgut of unfed ticks, which is mostly beta-sheet. The surface of OspC that would project away from the spirochete's membrane has a region of strong negative electrostatic potential which may be involved in binding to positively charged host ligands. This feature is present only on OspCs from strains known to cause invasive human disease.
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[[Category: Borreliella burgdorferi]]
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[[Category: Large Structures]]
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==About this Structure==
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[[Category: Dunn JJ]]
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1F1M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F1M OCA].
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[[Category: Eswaramoorthy S]]
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[[Category: Kumaran D]]
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==Reference==
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[[Category: Swaminathan S]]
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Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi., Kumaran D, Eswaramoorthy S, Luft BJ, Koide S, Dunn JJ, Lawson CL, Swaminathan S, EMBO J. 2001 Mar 1;20(5):971-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11230121 11230121]
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[[Category: Borrelia burgdorferi]]
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[[Category: Single protein]]
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[[Category: Dunn, J J.]]
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[[Category: Eswaramoorthy, S.]]
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[[Category: Kumaran, D.]]
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[[Category: Swaminathan, S.]]
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[[Category: Dimer]]
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[[Category: Hb19]]
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[[Category: Helical bundle]]
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[[Category: Lyme disease]]
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[[Category: Ospc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:46:54 2008''
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Current revision

CRYSTAL STRUCTURE OF OUTER SURFACE PROTEIN C (OSPC)

PDB ID 1f1m

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