1jty

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Current revision (08:46, 16 August 2023) (edit) (undo)
 
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<StructureSection load='1jty' size='340' side='right'caption='[[1jty]], [[Resolution|resolution]] 2.97&Aring;' scene=''>
<StructureSection load='1jty' size='340' side='right'caption='[[1jty]], [[Resolution|resolution]] 2.97&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1jty]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JTY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1jty]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JTY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JTY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ET:ETHIDIUM'>ET</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.97&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jt0|1jt0]], [[1jt6|1jt6]], [[1jtx|1jtx]], [[1jum|1jum]], [[1jup|1jup]], [[1jus|1jus]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ET:ETHIDIUM'>ET</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jty OCA], [https://pdbe.org/1jty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jty RCSB], [https://www.ebi.ac.uk/pdbsum/1jty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jty ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jty OCA], [https://pdbe.org/1jty PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jty RCSB], [https://www.ebi.ac.uk/pdbsum/1jty PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jty ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/QACR_STAAU QACR_STAAU]] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.
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[https://www.uniprot.org/uniprot/QACR_STAAU QACR_STAAU] Transcriptional repressor of qacA. Binds to IR1, an unusually long 28 bp operator, which is located downstream from the qacA promoter and overlaps its transcription start site. QacR is induced from its IR1 site by binding to one of many structurally dissimilar cationic lipophilic compounds, which are also substrates of QacA.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Brennan, R G]]
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[[Category: Staphylococcus aureus]]
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[[Category: Brown, M H]]
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[[Category: Brennan RG]]
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[[Category: Grkovic, S]]
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[[Category: Brown MH]]
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[[Category: Miller, M C]]
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[[Category: Grkovic S]]
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[[Category: Schumacher, M A]]
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[[Category: Miller MC]]
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[[Category: Skurray, R A]]
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[[Category: Schumacher MA]]
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[[Category: Cationic lipophilic drug]]
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[[Category: Skurray RA]]
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[[Category: Multidrug binding]]
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[[Category: Multidrug recognition mechanism]]
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[[Category: Qaca]]
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[[Category: Qacr]]
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[[Category: Repressor]]
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[[Category: Transcription]]
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Current revision

Crystal structure of the multidrug binding transcriptional regulator QacR bound to ethidium

PDB ID 1jty

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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