GTP-binding protein 3D structures

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Line 6: Line 6:
*'''Small GTP-binding protein'''
*'''Small GTP-binding protein'''
-
**[[2eki]] – hGBP TGS domain – NMR - human<br />
+
**[[2eki]] – hGBP TGS domain – NMR – human<br />
 +
**[[6k1z]] – hGBP1<br />
 +
**[[7e58]] – hGBP2<br />
**[[3r7w]], [[4arz]] – yGtr1 + Gtr2 – yeast<br />
**[[3r7w]], [[4arz]] – yGtr1 + Gtr2 – yeast<br />
 +
**[[1ni3]] – fyYchF – fission yeast<br />
**[[3kxk]], [[3kxl]] – SsHflx (mutant) - ''Sulfolobus solfataricus''<br />
**[[3kxk]], [[3kxl]] – SsHflx (mutant) - ''Sulfolobus solfataricus''<br />
**[[2qtf]] – SsHflx<br />
**[[2qtf]] – SsHflx<br />
**[[2dyk]] – TtEngA N terminal – ''Thermus thermophilus'' - Cryo EM<br />
**[[2dyk]] – TtEngA N terminal – ''Thermus thermophilus'' - Cryo EM<br />
-
**[[5a9v]], [[4zci]] – EcBipA – ''Escherichia coli'' <br />
+
**[[4zci]], [[5a9v]] – EcBipA – ''Escherichia coli'' <br />
**[[4zck]] – EcBipA C-terminal<br />
**[[4zck]] – EcBipA C-terminal<br />
 +
**[[8ewh]] – BipA – ''Salmonella typhimurium''<br />
**[[1sul]] – BsYsxC - ''Bacillus subtilis''<br />
**[[1sul]] – BsYsxC - ''Bacillus subtilis''<br />
**[[2dwq]] – TtYchF<br />
**[[2dwq]] – TtYchF<br />
Line 18: Line 22:
**[[1wxq]] – GBP – ''Pyrococcus horikoshii''<br />
**[[1wxq]] – GBP – ''Pyrococcus horikoshii''<br />
**[[1yr6]] - PaGBP – ''Pyrococcus abyssi''<br />
**[[1yr6]] - PaGBP – ''Pyrococcus abyssi''<br />
-
**[[1ni3]] – YchF – ''Schizosaccharomyces pombe''<br />
+
**[[5owv]], [[5oxf]] – GBP – ''Campylobacter jejuni''<br />
-
**[[5oxf]], [[5owv]] – GBP – ''Campylobacter jejuni''<br />
+
*GTP-binding protein complex with nucleotide
*GTP-binding protein complex with nucleotide
Line 32: Line 35:
**[[2b92]] - hGBP N terminal + GDP<br />
**[[2b92]] - hGBP N terminal + GDP<br />
**[[2bc9]] - hGBP N terminal + GPPNHP<br />
**[[2bc9]] - hGBP N terminal + GPPNHP<br />
-
**[[2gao]] - hSar1A + GDP<br />
+
**[[2gao]], [[8dzn]] - hSar1A + GDP<br />
 +
**[[8dzo]], [[8dzt]], [[8e0d]], [[8e0h]] - hSar1A (mutant) + G4P<br />
 +
**[[8dzm]] - hSar1A + PPGPP<br />
 +
**[[8e0a]] - hSar1B + GDP<br />
 +
**[[8e0c]] - hSar1B (mutant) + GTP<br />
 +
**[[6eg8]] – hGBP subunits α-1,β-1,γ-2 + GDP<br />
 +
**[[6au6]] – hGBP subunit α-1 + GDP<br />
 +
**[[6vkj]] – hGBP2 G domain + GDP<br />
 +
**[[7ckf]], [[7e5a]] – hGBP5 + GDP<br />
 +
**[[1git]], [[4aii]] - rRem2 G domain + GDP - rat<br />
**[[2fa9]] – ChSar1B (mutant) + GDP – Chinese hamster<br />
**[[2fa9]] – ChSar1B (mutant) + GDP – Chinese hamster<br />
**[[2fmx]] - ChSar1B + GDP<br />
**[[2fmx]] - ChSar1B + GDP<br />
**[[1yzn]] – yPt1 + GPPNHP<br />
**[[1yzn]] – yPt1 + GPPNHP<br />
 +
**[[7kmt]] – yPt1 in TRAPPII complex – Cryo EM<br />
**[[1ky2]] – yPt7 + GPPNHP<br />
**[[1ky2]] – yPt7 + GPPNHP<br />
**[[1ky3]] – yPt7 + GDP<br />
**[[1ky3]] – yPt7 + GDP<br />
Line 43: Line 56:
**[[3rwm]], [[3rwo]] – yPt32 + GPPNHP<br />
**[[3rwm]], [[3rwo]] – yPt32 + GPPNHP<br />
**[[1ek0]] – yPt51 + GPPNHP<br />
**[[1ek0]] – yPt51 + GPPNHP<br />
-
**[[2hjg]], [[4dcs]], [[4dct]], [[4dcu]], [[4dcv]], [[4kyu]], [[5mbs]] – BsEngA + GDP<br />
+
**[[6x90]] – ySar1 + Sec12<br />
 +
**[[8bsh]] – ySar1 + Sec23 + Sec24 – Cryo EM<br />
 +
**[[6zga]] – ySar1 + Sec23 + Sec24 + peptide – Cryo EM<br />
 +
**[[2hjg]], [[4dcs]], [[4dct]], [[4dcu]], [[4dcv]], [[5mbs]], [[5x4b]] – BsEngA + GDP<br />
**[[5m7h]] – BsEngA + GMPPNP<br />
**[[5m7h]] – BsEngA + GMPPNP<br />
**[[5x4b]] – BsEngA N-terminal + GDP<br />
**[[5x4b]] – BsEngA N-terminal + GDP<br />
Line 52: Line 68:
**[[2dby]] – TtYchF + GDP<br />
**[[2dby]] – TtYchF + GDP<br />
**[[1wf3]] – Tt1341 + GNP<br />
**[[1wf3]] – Tt1341 + GNP<br />
-
**[[5a9y]], [[4zcm]] – EcBipA + G-4-phosphate <br />
+
**[[4zcm]], [[5a9y]] – EcBipA + G-4-phosphate <br />
-
**[[5a9x]], [[5a9w]], [[4zcl]] – EcBipA + GDP <br />
+
**[[4zcl]], [[5a9w]], [[5a9x]] – EcBipA + GDP <br />
**[[5dn8]] – EngA + GDP – ''Coxiella burnetti''<br />
**[[5dn8]] – EngA + GDP – ''Coxiella burnetti''<br />
**[[1yr7]], [[1yr8]] – PaGBP + GTP<br />
**[[1yr7]], [[1yr8]] – PaGBP + GTP<br />
**[[1yr9]], [[1yra]], [[1yrb]], [[2oxr]] – PaGBP + GDP<br />
**[[1yr9]], [[1yra]], [[1yrb]], [[2oxr]] – PaGBP + GDP<br />
-
**[[3kxi]], [[2qth]] – SsHflx + GDP<br />
+
**[[2qth]], [[3kxi]] – SsHflx + GDP<br />
 +
**[[6xrs]] – GBP EngA + GDP – ''Neisseria gonorrhoeae''<br />
*GTP-binding protein complex with protein
*GTP-binding protein complex with protein
 +
**[[6cmo]], [[6qno]] – hGBP subunits α-1,β-1,γ-t1 + antibody + rhodopsin – Cryo EM<br />
 +
**[[6oij]], [[6oik]] – hGBP subunits α-1,β-1,γ-2 + antibody + AChR – Cryo EM<br />
 +
**[[6ot0]] – hGBP subunits α-1,β-1,γ-2 + antibody + smoothend homolog – Cryo EM<br />
 +
**[[6d9h]] – hGBP subunits α-1,β-1,γ-2 + AChR/adenosine receptor – Cryo EM<br />
 +
**[[6g79]] – hGBP subunits α-1,β-1,γ-2 + hydroxytryptamine receptor – Cryo EM<br />
 +
**[[6li3]] – hGBP subunits α-1,β-1,γ-2 + nanobody + G protein coupled receptor – Cryo EM<br />
 +
**[[6e3y]] – hGBP subunits α-1,β-1,γ-2 + nanobody + calcitonin receptor + receptor activity-modifying protein – Cryo EM<br />
 +
**[[6pb0]], [[6pb1]] – hGBP subunits α-1,β-1,γ-2 + nanobody + corticotropin-releasing factor receptor + urocortin – Cryo EM<br />
 +
**[[7joz]] – hGBP subunits α-1,β-1,γ-2 + nanobody + dopamine receptor + agonist – Cryo EM<br />
 +
**[[6wi9]], [[6wzg]] – hGBP subunits α-1,β-1,γ-2 + nanobody + secretin receptor + secretin – Cryo EM<br />
 +
**[[6lmk]], [[6lml]], [[6wpw]] – hGBP subunits α-1,β-1,γ-2 + nanobody + glucagon receptor + glucagon – Cryo EM<br />
 +
**[[6b3j]] – hGBP subunits α-1,β-1,γ-2 + nanobody + glucagon-like peptide receptor + exendin – Cryo EM<br />
 +
**[[6osa]] – hGBP subunits α-1,β-1,γ-2 + JMV449 + neurotensin receptor – Cryo EM<br />
 +
**[[6os9]] – hGBP subunits α-1,β-1,γ-2 + JMV449 + scFv + neurotensin receptor – Cryo EM<br />
 +
**[[7dfl]] – hGBP subunits α-1,β-1,γ-2 + scFv + histamine receptor + histamine – Cryo EM<br />
 +
**[[6kpf]], [[6kpg]] – hGBP subunits α-1,β-1,γ-2 + scFv + cannabinoid receptor – Cryo EM<br />
 +
**[[6lfm]], [[6lfo]] – hGBP subunits α-1,β-1,γ-2 + scFv + interleukin-8 + C-X-C chemokine receptor – Cryo EM<br />
 +
**[[6loj]] – hGBP1 + invasion plasmid antigen + GDP<br />
 +
**[[6m8s]] – bGBP subunits b-1, g-2 + KCTD12<br />
 +
**[[6dde]], [[6ddf]] – bGBP subunits α-1,β-1,γ-2 + scFv + opioid receptor + DAMGO – Cryo EM<br />
 +
**[[6b20]] – bGBP subunits β-1,γ-t1 (mutant) + nanobody – bovine<br />
 +
**[[6r3q]], [[6r4o]], [[6r4p]] – bGBP subunit α-1 + adenylae cyclase – Cryo EM<br />
 +
**[[7jjo]] – bGBP subunits α-1,β-1,γ-2 + nanobody + b1 adrenergic receptor – Cryo EM<br />
 +
**[[6mhe]] – rGBP subunit α-1 + peptide + GDP<br />
 +
**[[6mhf]] – rGBP subunit α-1 + girdin + GDP<br />
 +
**[[6tyl]], [[6ukt]] – rGBP subunit α-1 + nanobody + RIC8A <br />
 +
**[[6n9g]] – mGBP subunit β-5 + RGS7 - mouse<br />
**[[3cue]] – yPt1 + transport protein subunits<br />
**[[3cue]] – yPt1 + transport protein subunits<br />
-
**[[2bcg]], [[1ukv]] - yPt1 + secretory pathway GDP-dissociation inhibitor<br />
+
**[[1ukv]], [[2bcg]] - yPt1 + secretory pathway GDP-dissociation inhibitor<br />
 +
**[[9ayr]] – yPt6 + RIC1 + RGP1 – Cryo EM<br />
**[[3cpj]] – yPt31 + Rab GDP-dissociation inhibitor<br />
**[[3cpj]] – yPt31 + Rab GDP-dissociation inhibitor<br />
 +
**[[7e8t]], [[7ea3]], [[7u05]], [[7u06]] - yPt32 in TRAPPII complex – Cryo EM<br />
**[[1m2o]] – ySar1 + protein transport protein sec23<br />
**[[1m2o]] – ySar1 + protein transport protein sec23<br />
 +
**[[2qtv]] - ySar1 + protein transport protein sec23 + GNP<br />
**[[6gni]] - ySar1 + protein transport protein sec23 + Sec24 + GNP<br />
**[[6gni]] - ySar1 + protein transport protein sec23 + Sec24 + GNP<br />
-
**[[6gwp]] – yGtr1 + Gtr2 + Meh1 + Ego2 + Slm4 + GNP<br />
+
**[[6jwp]] – yGtr1 + Gtr2 + Meh1 + Ego2 + Slm4 + GNP<br />
 +
**[[8fw5]] – yGtr1 + Gtr2 in Gtr-LAM complex – Cryo EM<br />
**[[3syn]] – BsFlhf + ATP-binding protein<br />
**[[3syn]] – BsFlhf + ATP-binding protein<br />
Line 72: Line 120:
**[[4idn]] – hGDP3 cytoplasmic domain + GNP<br />
**[[4idn]] – hGDP3 cytoplasmic domain + GNP<br />
-
**[[4ido]], [[4idq]], [[3q5d]], [[3q5e]], [[3qnu]], [[3qof]] – hGDP3 cytoplasmic domain + GDP<br />
+
**[[3q5d]], [[3q5e]], [[3qnu]], [[3qof]], [[4ido]], [[4idq]], [[6b9g]], [[6xjn]], [[7ol3]] – hGDP3 cytoplasmic domain + GDP<br />
-
**[[6b9f]], [[6b9e]], [[6b9d]] – hGDP3 cytoplasmic domain (mutant) + GDP<br />
+
**[[6b9d]], [[6b9e]], [[6b9f]] – hGDP3 cytoplasmic domain (mutant) + GDP<br />
* GTP-binding protein LepA
* GTP-binding protein LepA
Line 102: Line 150:
**[[2gf0]] – hDiRas1 + GDP<br />
**[[2gf0]] – hDiRas1 + GDP<br />
**[[2erx]] – hDiRas2 + Pi + GDP<br />
**[[2erx]] – hDiRas2 + Pi + GDP<br />
-
**[[3x1z]], [[3x1y]], [[3x1x]], [[3x1w]] – hRab-1B (mutant) + GPPNHP<br />
+
**[[3x1w]], [[3x1x]], [[3x1y]], [[3x1z]] – hRab-1B (mutant) + GPPNHP<br />
**[[1yu9]] - hRab-4A + GPPNHP<br />
**[[1yu9]] - hRab-4A + GPPNHP<br />
**[[1yzq]] - hRab-6 + GNP<br />
**[[1yzq]] - hRab-6 + GNP<br />
 +
**[[6hh2]] – hRab-7L1 + GDP<br />
**[[1x3s]] – hRab-18 + GPPNHP
**[[1x3s]] – hRab-18 + GPPNHP
**[[6huf]] - hRab-27A + GNP<br />
**[[6huf]] - hRab-27A + GNP<br />
 +
**[[7opp]], [[7opq]], [[7opr]] - hRab-27A/SLP2A + GNP<br />
 +
**[[6ff8]] - hRab-32 + GTP<br />
 +
**[[6hdu]], [[6s5h]] - hRab-38 + GTP<br />
**[[6s6a]], [[6s6d]] - hRagA (mutant) + RagC (mutant) + GDP + GTP<br />
**[[6s6a]], [[6s6d]] - hRagA (mutant) + RagC (mutant) + GDP + GTP<br />
**[[2atx]] – hTc10 + GPPNHP<br />
**[[2atx]] – hTc10 + GPPNHP<br />
**[[1g16]] – ySec4 + GDP<br />
**[[1g16]] – ySec4 + GDP<br />
**[[1g17]] - ySec4 + GIP<br />
**[[1g17]] - ySec4 + GIP<br />
 +
**[[6o62]] – Sec4 + GDP – ''Candida albicans''<br />
*Ras-related small GTP-binding protein complex with protein
*Ras-related small GTP-binding protein complex with protein
Line 120: Line 173:
**[[6ba6]] – hRab-1B + talin-1<br />
**[[6ba6]] – hRab-1B + talin-1<br />
**[[4m8n]] – hRab-1B + plexin<br />
**[[4m8n]] – hRab-1B + plexin<br />
 +
**[[6kyk]], [[7c7i]] – hRab-1B + Shank3<br />
 +
**[[7c7j]] – hRab-1B (mutant) + Shank3<br />
 +
**[[6uzk]] – hRab-1B + KRIT1 + GNP<br />
**[[4dxa]] – hRab-1B (mutant) + KRIT1<br />
**[[4dxa]] – hRab-1B (mutant) + KRIT1<br />
-
**[[4hdq]], [[4hdo]] – hRab-1B + HEG1 + KRIT1<br />
+
**[[4hdo]], [[4hdq]] – hRab-1B + HEG1 + KRIT1<br />
**[[6axf]] – hRab-1B + Ras guanyl-releasing protein 2<br />
**[[6axf]] – hRab-1B + Ras guanyl-releasing protein 2<br />
**[[5kho]] – hRab-1B + Ras-interacting protein 1<br />
**[[5kho]] – hRab-1B + Ras-interacting protein 1<br />
-
**[[4mh0]], [[4mgz]], [[4mgy]], [[4mgk]], [[4mgi]] - hRap-1B + Rap guanine nucleotide exchange factor 4<br />
+
**[[4mgi]], [[4mgk]], [[4mgy]], [[4mgz]], [[4mh0]] - hRap-1B + Rap guanine nucleotide exchange factor 4<br />
 +
**[[6sku]] – hRab-1B + phosphocholine transferase + GDP<br />
 +
**[[6sq2]] – hRab-8A + RILPL2 + GTP<br />
**[[1z0k]] – hRab-4 + rabenosyn-5<br />
**[[1z0k]] – hRab-4 + rabenosyn-5<br />
**[[3tw8]] – hRab-1C + DENND<br />
**[[3tw8]] – hRab-1C + DENND<br />
**[[4ojk]] – hRab-11B + cGMP-dependent protein kinase 2<br />
**[[4ojk]] – hRab-11B + cGMP-dependent protein kinase 2<br />
 +
**[[6zay]] – hRab-33B + autophagy-related protein + GDP<br />
**[[6ekk]] – hRab-35 + connecdenn + GDP<br />
**[[6ekk]] – hRab-35 + connecdenn + GDP<br />
**[[6if2]] – hRab-35 (mutant) + iporin + GTP<br />
**[[6if2]] – hRab-35 (mutant) + iporin + GTP<br />
**[[6if3]] – hRab-35 (mutant) + ACAP2 + GTP<br />
**[[6if3]] – hRab-35 (mutant) + ACAP2 + GTP<br />
**[[6ces]] – hRag-C (mutant) + NPRL2 + NPRL3 + DEPDC5 + GNP – Cryo EM<br />
**[[6ces]] – hRag-C (mutant) + NPRL2 + NPRL3 + DEPDC5 + GNP – Cryo EM<br />
-
**[[6ehr]], [[5x6v]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5<br />
+
**[[5x6v]], [[6ehr]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5<br />
**[[6u62]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5 + GTP + GDP – Cryo EM<br />
**[[6u62]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5 + GTP + GDP – Cryo EM<br />
 +
**[[7uxc]] – hRag-A + hRag-C in MtorC1-TFEB-RAG-ragulator complex + GTP + GDP – Cryo EM<br />
 +
**[[8dhb]] – hRag-A + hRag-C in FLCN-Gap complex – Cryo EM<br />
 +
**[[6wj2]], [[6wj3]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5 + GDP – Cryo EM<br />
**[[6nzd]], [[6ulg]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5 + folliculin + folliculin-interacting protein + GDP – Cryo EM<br />
**[[6nzd]], [[6ulg]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5 + folliculin + folliculin-interacting protein + GDP – Cryo EM<br />
**[[6sb2]] – hRag-A + hRag-C + Mtor + Torc + Raptor + GDP + GTP – Cryo EM<br />
**[[6sb2]] – hRag-A + hRag-C + Mtor + Torc + Raptor + GDP + GTP – Cryo EM<br />
 +
**[[7t3a]], [[7t3b]], [[7t3c]] – hRag-A + hRag-C in GATOR1-RAG-Ragulator complex – Cryo EM<br />
 +
**[[7ux2]] – hRag-A + hRag-C in RAPTOR-TFEB1-RAG-Ragulator complex – Cryo EM<br />
 +
**[[7uxh]] – hRag-A + hRag-C in TORC1-TFEB1-RAG-Ragulator complex – Cryo EM<br />
**[[6sb0]] – hRag-A + hRag-C + Mtor + Torc + Raptor + Pro-rich Akt1 substrate + GDP + GTP – Cryo EM<br />
**[[6sb0]] – hRag-A + hRag-C + Mtor + Torc + Raptor + Pro-rich Akt1 substrate + GDP + GTP – Cryo EM<br />
**[[6oq3]], [[6oq4]] – hRap-1B + krev interacting trapped protein + GNP<br />
**[[6oq3]], [[6oq4]] – hRap-1B + krev interacting trapped protein + GNP<br />
 +
**[[6sur]], [[6y09]] – mRab-33B (mutant) + autophagy-related protein + GTP<br />
*'''Interferon-induced GTP-binding protein'''
*'''Interferon-induced GTP-binding protein'''
Line 150: Line 216:
**[[4x0r]] – hMx2 stalk region (mutant)<br />
**[[4x0r]] – hMx2 stalk region (mutant)<br />
**[[4whj]] – hMx2 residues 84-715 (mutant)<br />
**[[4whj]] – hMx2 residues 84-715 (mutant)<br />
 +
**[[5uot]] – hMxB – Cryo EM<br />
*'''Rho-related small GTP-binding protein'''
*'''Rho-related small GTP-binding protein'''
Line 157: Line 224:
*Rho-related small GTP-binding protein complex with nucleotide
*Rho-related small GTP-binding protein complex with nucleotide
 +
**[[6d71]] – hRho1 + GTP<br />
**[[2cls]] – hRho6 + GTP<br />
**[[2cls]] – hRho6 + GTP<br />
**[[2fv8]] - hRhoB + GDP<br />
**[[2fv8]] - hRhoB + GDP<br />
Line 166: Line 234:
**[[1m7b]] - hRhoE + GTP<br />
**[[1m7b]] - hRhoE + GTP<br />
**[[1gwn]] - mRhoE + GTP <br />
**[[1gwn]] - mRhoE + GTP <br />
 +
**[[8etd]] – fyRho1 + GDP <br />
*Rho-related small GTP-binding protein complex with protein
*Rho-related small GTP-binding protein complex with protein
**[[2v55]] – hRhoE + Rho-associated protein kinase<br />
**[[2v55]] – hRhoE + Rho-associated protein kinase<br />
 +
**[[8b2k]] – hRhoE + 14-3-3 protein<br />
**[[3q3j]] – hRho6 + plexin-A2 nucleotide-binding domain<br />
**[[3q3j]] – hRho6 + plexin-A2 nucleotide-binding domain<br />
**[[2rex]] – hRho6 + plexin-B1<br />
**[[2rex]] – hRho6 + plexin-B1<br />
 +
**[[7kdc]] - hRhoD + plexin-B2 + GNP<br />
**[[1cc0]] – hRhoA + GDP-dissociation inhibitor + GDP<br />
**[[1cc0]] – hRhoA + GDP-dissociation inhibitor + GDP<br />
**[[6bca]] - hRhoA + kinase anchor protein + GTP<br />
**[[6bca]] - hRhoA + kinase anchor protein + GTP<br />
**[[6sge]] - hRhoB + nanobody + GTP<br />
**[[6sge]] - hRhoB + nanobody + GTP<br />
 +
**[[6uka]] - hRhoG + ELMO + GNP<br />
 +
**[[7y4a]] - hRhoG + ELMO + GDP<br />
 +
**[[8xm7]], [[8zj2]] - hRhoG (mutant) + ELMO + DOCK5 + GTP - Cryo EM<br />
**[[3a58]] – yRho1 (mutant) + exocyst complex component Sec3 + cancidas<br />
**[[3a58]] – yRho1 (mutant) + exocyst complex component Sec3 + cancidas<br />
 +
**[[8wla]] – yRho1 (mutant) + FKS1 – Cryo EM<br />
-
*G25K GTP-binding protein or cell division control protein 42 homolog
+
 
 +
*G25K GTP-binding protein or cell division control protein 42 homolog or Cdc42
**[[1a4r]] - hCdc42 (mutant) + GDP<br />
**[[1a4r]] - hCdc42 (mutant) + GDP<br />
Line 188: Line 264:
**[[2dfk]] – hCdc42 + collybistin II<br />
**[[2dfk]] – hCdc42 + collybistin II<br />
**[[2wm9]], [[2wmn]], [[2wmo]] - hCdc42 + DOCK9<br />
**[[2wm9]], [[2wmn]], [[2wmo]] - hCdc42 + DOCK9<br />
 +
**[[8i5f]] - hCdc42 + DOCK10<br />
**[[3eg5]] - hCdc42 + protein diaphanous homolog 1 + GMPPNP<br />
**[[3eg5]] - hCdc42 + protein diaphanous homolog 1 + GMPPNP<br />
**[[3gcg]] - hCdc42 + MAP<br />
**[[3gcg]] - hCdc42 + MAP<br />
Line 208: Line 285:
**[[4itr]] – hCdc42 + AMP-protein transferase + GDP + AMP<br />
**[[4itr]] – hCdc42 + AMP-protein transferase + GDP + AMP<br />
**[[6aj4]], [[6ajl]] - hCdc42 (mutant) + dedicator of cytokinesis protein<br />
**[[6aj4]], [[6ajl]] - hCdc42 (mutant) + dedicator of cytokinesis protein<br />
-
**[[5upl]], [[5upk]] - hCdc42 + PAK 4<br />
+
**[[5upk]], [[5upl]] - hCdc42 + PAK 4<br />
**[[5fi1]] - hCdc42 + PTDINS dependent RAC exchanger<br />
**[[5fi1]] - hCdc42 + PTDINS dependent RAC exchanger<br />
**[[6siu]] - hCdc42 + IBPA + GDP<br />
**[[6siu]] - hCdc42 + IBPA + GDP<br />
Line 228: Line 305:
**[[2px0]] – BsFlhF + GMP-PNP <br />
**[[2px0]] – BsFlhF + GMP-PNP <br />
**[[2px3]] – BsFlhF + GTP<br />
**[[2px3]] – BsFlhF + GTP<br />
 +
**[[9en1]] – FlhF – Shewanlla putrefaciens<br />
*'''Small GTP-binding protein'''
*'''Small GTP-binding protein'''
Line 238: Line 316:
**[[3ieu]] – EcERA + GDP <br />
**[[3ieu]] – EcERA + GDP <br />
**[[3iev]] – AaERA + RNA + Mg-GNP <br />
**[[3iev]] – AaERA + RNA + Mg-GNP <br />
 +
**[[7c1o]] – AaERA + GDP <br />
**[[1x1l]] – TtERA + RNA – Cryo EM<br />
**[[1x1l]] – TtERA + RNA – Cryo EM<br />
**[[1x18]] – TtERA + RNA + RPS2 + RPS7 + RPS11 + RPS18 – Cryo EM<br />
**[[1x18]] – TtERA + RNA + RPS2 + RPS7 + RPS11 + RPS18 – Cryo EM<br />
Line 247: Line 326:
**[[1xtr]] - hRheb + GPPNHP<br />
**[[1xtr]] - hRheb + GPPNHP<br />
**[[3sea]] - hRheb + GDP + GNP<br />
**[[3sea]] - hRheb + GDP + GNP<br />
-
**[[6bt0]], [[6bsx]] - hRheb + GDP + inhibitor<br />
+
**[[6bsx]], [[6bt0]] - hRheb + GDP + inhibitor<br />
**[[3t5g]] – hRheb + GMP-PDE delta<br />
**[[3t5g]] – hRheb + GMP-PDE delta<br />
 +
**[[6bcu]] – hRheb + mTORC1 – Cryo EM<br />
**[[4o25]] – mRheb + GTP - mouse<br />
**[[4o25]] – mRheb + GTP - mouse<br />
**[[4o2l]] - mRheb (mutant) + GTP <br />
**[[4o2l]] - mRheb (mutant) + GTP <br />
Line 257: Line 337:
*'''Small GTP-binding protein Gem'''
*'''Small GTP-binding protein Gem'''
-
**[[2cjw]], [[2ht6]], [[2g3y]] – hGem G domain + GDP<br />
+
**[[2cjw]], [[2g3y]], [[2ht6]] – hGem G domain + GDP<br />
*'''Small GTP-binding protein Ran'''
*'''Small GTP-binding protein Ran'''
Line 265: Line 345:
*Ran binary complex
*Ran binary complex
-
**[[3gj0]], [[5ciw]], [[5cit]], [[5ciq]] – hRan + GDP<br />
+
**[[3gj0]], [[5ciq]], [[5cit]], [[5ciw]] – hRan + GDP<br />
**[[5cj2]] – hRan (mutant) + GDP<br />
**[[5cj2]] – hRan (mutant) + GDP<br />
**[[1i2m]] – hRan + regulator of chromosome condensation 1<br />
**[[1i2m]] – hRan + regulator of chromosome condensation 1<br />
Line 296: Line 376:
**[[1k5d]], [[5zpu]] – hRan + Ran-specific GTPase-activating protein + Ran GTPase activating protein 1 + GTP analog<br />
**[[1k5d]], [[5zpu]] – hRan + Ran-specific GTPase-activating protein + Ran GTPase activating protein 1 + GTP analog<br />
**[[1k5g]] – hRan + Ran-specific GTPase-activating protein + Ran GTPase activating protein 1 + GDP <br />
**[[1k5g]] – hRan + Ran-specific GTPase-activating protein + Ran GTPase activating protein 1 + GDP <br />
-
**[[4gpt]], [[4gmx]], [[4hat]], [[4hb2]], [[4hb3]] – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP <br />
+
**[[4gmx]], [[4gpt]], [[4hat]], [[4hb2]], [[4hb3]] – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP <br />
**[[4hat]], [[4hau]], [[4hav]], [[4haw]], [[4hax]], [[4hay]], [[4haz]], [[4hb0]], [[4hb4]] – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP + antibiotic<br />
**[[4hat]], [[4hau]], [[4hav]], [[4haw]], [[4hax]], [[4hay]], [[4haz]], [[4hb0]], [[4hb4]] – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP + antibiotic<br />
**[[5jlj]] – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP + inhibitor<br />
**[[5jlj]] – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP + inhibitor<br />
**[[4wvf]] – hRan + Ran-specific GTPase-activating protein + CRM1P + GNP + inhibitor<br />
**[[4wvf]] – hRan + Ran-specific GTPase-activating protein + CRM1P + GNP + inhibitor<br />
-
**[[6cit]], [[6kft]] – hRan + Ran-specific GTPase-activating protein + exportin + NS2 + GNP<br />
+
**[[6cit]], [[9vm1]] – hRan + Ran-specific GTPase-activating protein + exportin + NS2 + GNP<br />
**[[6x2r]] – hRan + Ran-specific GTPase-activating protein + exportin + Eif4E + GNP<br />
**[[6x2r]] – hRan + Ran-specific GTPase-activating protein + exportin + Eif4E + GNP<br />
**[[6x2u]], [[6x2v]], [[6x2w]] – hRan + Ran-specific GTPase-activating protein + exportin + Pki-alpha peptide + GNP<br />
**[[6x2u]], [[6x2v]], [[6x2w]] – hRan + Ran-specific GTPase-activating protein + exportin + Pki-alpha peptide + GNP<br />
**[[6x2x]] – hRan + Ran-specific GTPase-activating protein + exportin + Mkk1 peptide + GNP<br />
**[[6x2x]] – hRan + Ran-specific GTPase-activating protein + exportin + Mkk1 peptide + GNP<br />
**[[6x2y]] – hRan + Ran-specific GTPase-activating protein + exportin + diaphanous homolog peptide + GNP<br />
**[[6x2y]] – hRan + Ran-specific GTPase-activating protein + exportin + diaphanous homolog peptide + GNP<br />
-
**[[6a3e]], [[6a3c]], [[6a3b]], [[6a3a]], [[6a38]] – hRan + Ran-specific GTPase-activating protein + exportin + NES + GTP<br />
+
**[[6a38]], [[6a3a]], [[6a3b]], [[6a3c]], [[6a3e]] – hRan + Ran-specific GTPase-activating protein + exportin + NES + GTP<br />
-
**[[5ytb]], [[5yst]], [[5yro]] – hRan (mutant) + Ran-specific GTPase-activating protein + exportin + GTP<br />
+
**[[5yro]], [[5yst]], [[5ytb]] – hRan (mutant) + Ran-specific GTPase-activating protein + exportin + GTP<br />
**[[5ysu]] – hRan (mutant) + Ran-specific GTPase-activating protein + exportin + GTP + plumbagin<br />
**[[5ysu]] – hRan (mutant) + Ran-specific GTPase-activating protein + exportin + GTP + plumbagin<br />
-
**[[5uww]], [[5uwu]], [[5uwt]], [[5uws]], [[5uwr]], [[5uwq]], [[5uwp]], [[5uwo]], [[5uwj]], [[5uwi]], [[5uwh]], [[5dif]], [[5di9]], [[5dhf]], [[5dha]], [[5dh9]] – hRan + Ran-specific GTPase-activating protein + exportin 1 + peptide<br />
+
**[[5di9]], [[5dif]], [[5dh9]], [[5dha]], [[5dhf]], [[5uwh]], [[5uwi]], [[5uwj]], [[5uwo]], [[5uwp]], [[5uwq]], [[5uwr]], [[5uws]], [[5uwt]], [[5uwu]], [[5uww]] – hRan + Ran-specific GTPase-activating protein + exportin 1 + peptide<br />
**[[3zjy]] – hRan (mutant) + importin 13 + EIF-1A + GTP <br />
**[[3zjy]] – hRan (mutant) + importin 13 + EIF-1A + GTP <br />
**[[6q84]] – hRan (mutant) + importin β-like protein + EIF-4D + GTP<br />
**[[6q84]] – hRan (mutant) + importin β-like protein + EIF-4D + GTP<br />
Line 318: Line 398:
**[[3m1i]] – yRan + Ran-specific GTPase-activating protein + exportin 1 + GTP <br />
**[[3m1i]] – yRan + Ran-specific GTPase-activating protein + exportin 1 + GTP <br />
-
*Small GTP-binding protein
 
-
**[[5kh0]] - GBP – ''Thermosipho melanesiensis''<br />
+
*'''Nucleolar GTP-binding protein 1'''
-
 
+
-
*Small GTP-binding protein ERA
+
-
 
+
-
**[[1ega]] – EcERA <br />
+
-
**[[3ieu]] – EcERA + GDP <br />
+
-
**[[3iev]] – AaERA + RNA + Mg-GNP <br />
+
-
**[[1x1l]] – TtERA + RNA – Cryo EM<br />
+
-
**[[1x18]] – TtERA + RNA + RPS2 + RPS7 + RPS11 + RPS18 – Cryo EM<br />
+
-
 
+
-
*Small GTP-binding protein Gem
+
-
 
+
-
**[[2cjw]], [[2ht6]], [[2g3y]] – hGem G domain + GDP<br />
+
-
 
+
-
*Small GTP-binding protein Rheb
+
-
 
+
-
**[[1xtq]], [[5yxh]] – hRheb + GDP<br />
+
-
**[[7bta]], [[7btc]] - hRheb (mutant) + GDP <br />
+
-
**[[1xts]] - hRheb + GTP<br />
+
-
**[[1xtr]] - hRheb + GPPNHP<br />
+
-
**[[7btd]] - hRheb (mutant) + GPPNHP <br />
+
-
**[[3sea]] - hRheb + GDP + GNP<br />
+
-
**[[6bt0]], [[6bsx]] - hRheb + GDP + inhibitor<br />
+
-
**[[3t5g]] – hRheb + GMP-PDE delta<br />
+
-
**[[4o25]] – mRheb + GTP - mouse<br />
+
-
**[[4o2l]] - mRheb (mutant) + GTP <br />
+
-
**[[4o2r]] - mRheb (mutant) + GDP <br />
+
-
**[[2l0x]] – rRheb + GDP<br />
+
 +
**[[7o9k]], [[7o9m]], [[7odt]], [[7of2]], [[7of4]], [[7of6]], [[7of7]], [[7oi6]], [[7pd3]] – hNGBP 1 in 39S mitoribosome – Cryo EM<br />
 +
**[[8pk0]], [[8qsj]] – hNGBP 1 in 60S mitoribosome – Cryo EM<br />
 +
**[[6lss]], [[6lu8]] – hNGBP 1 in 60S ribosome – Cryo EM<br />
 +
**[[8fkp]], [[8fkq]], [[8fkr]], [[8fks]], [[8fkt]], [[8fku]], [[8fkv]], [[8fkx]], [[8fky]], [[8fkz]], [[8fl0]], [[8fl2]], [[8fl3]], [[8fl4]], [[8fl6]], [[8fl7]], [[8fl9]], [[8fla]], [[8flc]], [[8fld]], [[8fle]], [[8flf]], [[8idt]], [[8idy]], [[8ie3]], [[8ine]], [[8inf]], [[8ink]], [[8ipd]], [[8ipx]], [[8ipy]], [[8ir1]], [[8ir3]], [[8rl2]], [[9qiw]] – hNGBP 1 in pre-60S ribosome – Cryo EM<br />
 +
**[[9hcf]], [[9hch]] – mNGBP 1 in 60S mitoribosome – Cryo EM<br />
 +
**[[3jct]], [[4v7f]], [[5jcs]], [[6c0f]], [[6elz]], [[6em1]], [[6em5]], [[6m62]], [[6n8l]], [[6ylg]], [[6ylh]], [[6ylx]], [[6yly]], [[7bt6]], [[7btb]], [[7nac]], [[7naf]], [[7of1]], [[7oh3]], [[7ohp]], [[7ohq]], [[7ohr]], [[7ohs]], [[7oht]], [[7ohv]], [[7ohw]], [[7ohx]], [[7ohy]], [[7r7a]], [[7r7c]], [[7u0h]], [[7ug6]], [[7uoo]], [[7uqb]], [[7uqz]], [[7uui]], [[7v08]], [[7z34]], [[8hfr]], [[8v83]], [[8v84]], [[8v87]] – yNGBP 1 in pre-60S ribosome – Cryo EM<br />
 +
**[[7nrc]] – yNGBP 1 in 80S ribosome – Cryo EM<br />
 +
**[[8esq]], [[8esr]], [[8etc]], [[8etg]], [[8eth]], [[8eti]], [[8etj]], [[8eup]], [[8euy]], [[8ev3]] – fyNGBP 1 in 60S ribosome – Cryo EM<br />
 +
**[[4csu]], [[5ady]], [[5zzm]], [[7bl2]], [[7bl3]], [[7bl4]], [[7bl5]], [[7bl6]], [[7yla]] – EcNGBP 1 in pre-50S ribosome – Cryo EM<br />
 +
**[[8g31]], [[8g34]] – EcNGBP 1 in 70S ribosome – Cryo EM<br />
 +
**[[5aa0]] – TtNGBP 1 in 50S ribosome – Cryo EM<br />
 +
**[[9bs0]], [[9bsl]], [[9bss]] – BsNGBP 1 in 50S ribosome – Cryo EM<br />
 +
**[[6yxx]] – NGBP 1 in 12S mitoribosome – ''Trypanosoma brucei'' - Cryo EM<br />
 +
**[[8a57]] – NGBP in 50S ribosome – ''Listeria monocytogenes'' - Cryo EM<br />
 +
**[[8uua]] – NGBP in 50S ribosome – ''Listeria innocua'' - Cryo EM<br />
 +
**[[8vk0]], [[8vk7]], [[8vki]], [[8vkw]], [[8vpk]], [[8vr4]], [[8vr8]], [[8vrl]] – MsNGBP in 50S ribosome – ''Mycobacterium smegmatis'' - Cryo EM<br />
 +
**[[8vio]] – MsNGBP 1 in 70S ribosome – Cryo EM<br />
 +
**[[8i9r]], [[8i9t]], [[8i9v]], [[8i9w]], [[8i9x]], [[8i9y]], [[8i9z]], [[8ia0]], [[8pv1]], [[8pv2]], [[8pv3]], [[8pv4]], [[8pv5]], [[8pv6]], [[8pv7]], [[8pv8]], [[8pvk]], [[8pvl]] – NGBP 1 in pre-60S ribosome – ''Chaetomium thermophilum'' - Cryo EM<br />
*'''Small GTPase h-Ras''' see [[GTPase HRas]]
*'''Small GTPase h-Ras''' see [[GTPase HRas]]

Current revision

3D Structures of GTP-binding protein

Updated on 06-August-2025



Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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