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5bkg

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'''Unreleased structure'''
 
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The entry 5bkg is ON HOLD
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==Cyro-EM structure of human Glycine Receptor alpha2-beta heteromer, glycine bound, (semi)open state==
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<StructureSection load='5bkg' size='340' side='right'caption='[[5bkg]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5bkg]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BKG FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bkg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bkg OCA], [https://pdbe.org/5bkg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bkg RCSB], [https://www.ebi.ac.uk/pdbsum/5bkg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bkg ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/GLRA2_HUMAN GLRA2_HUMAN] The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/GLRA2_HUMAN GLRA2_HUMAN] Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488, PubMed:26370147). Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677). Plays a role in synaptic plasticity (By similarity). Contributes to the generation of inhibitory postsynaptic currents, and is involved in the down-regulation of neuronal excitability (PubMed:25445488). Plays a role in cellular responses to ethanol (PubMed:23895467).[UniProtKB:Q7TNC8]<ref>PMID:15302677</ref> <ref>PMID:16144831</ref> <ref>PMID:2155780</ref> <ref>PMID:23895467</ref> <ref>PMID:25445488</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Aequorea victoria]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Wang W]]
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[[Category: Yu H]]

Current revision

Cyro-EM structure of human Glycine Receptor alpha2-beta heteromer, glycine bound, (semi)open state

PDB ID 5bkg

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