7pcv

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'''Unreleased structure'''
 
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The entry 7pcv is ON HOLD until Aug 04 2023
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==Crystal structure of RBM5 RRM1-zinc finger==
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<StructureSection load='7pcv' size='340' side='right'caption='[[7pcv]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
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Authors: Soni, K., Jagtap, P.K.A., Sattler, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7pcv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PCV FirstGlance]. <br>
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Description: Crystal structure of RBM5 RRM1-zinc finger
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.42&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Sattler, M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pcv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pcv OCA], [https://pdbe.org/7pcv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pcv RCSB], [https://www.ebi.ac.uk/pdbsum/7pcv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pcv ProSAT]</span></td></tr>
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[[Category: Jagtap, P.K.A]]
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</table>
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[[Category: Soni, K]]
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== Function ==
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[https://www.uniprot.org/uniprot/RBM5_HUMAN RBM5_HUMAN] Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.<ref>PMID:10949932</ref> <ref>PMID:12207175</ref> <ref>PMID:12581154</ref> <ref>PMID:15192330</ref> <ref>PMID:16585163</ref> <ref>PMID:18851835</ref> <ref>PMID:18840686</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Jagtap PKA]]
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[[Category: Sattler M]]
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[[Category: Soni K]]

Current revision

Crystal structure of RBM5 RRM1-zinc finger

PDB ID 7pcv

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