7pdz
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of capping protein bound to the barbed end of a cytoplasmic actin filament== | |
| + | <StructureSection load='7pdz' size='340' side='right'caption='[[7pdz]], [[Resolution|resolution]] 3.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7pdz]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PDZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PDZ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=DTH:D-THREONINE'>DTH</scene>, <scene name='pdbligand=EEP:(2~{S},4~{R})-2-azanyl-4-methyl-4,5-bis(oxidanyl)pentanoic+acid'>EEP</scene>, <scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pdz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pdz OCA], [https://pdbe.org/7pdz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pdz RCSB], [https://www.ebi.ac.uk/pdbsum/7pdz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pdz ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CAPZB_MOUSE CAPZB_MOUSE] F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity).[UniProtKB:A9XFX6][UniProtKB:P47756] | ||
| - | + | ==See Also== | |
| - | + | *[[Actin 3D structures|Actin 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Bos taurus]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: Bieling | + | [[Category: Synthetic construct]] |
| - | [[Category: Raunser | + | [[Category: Bieling P]] |
| - | [[Category: Schacks | + | [[Category: Funk J]] |
| + | [[Category: Merino F]] | ||
| + | [[Category: Raunser S]] | ||
| + | [[Category: Rottner K]] | ||
| + | [[Category: Schacks M]] | ||
Current revision
Structure of capping protein bound to the barbed end of a cytoplasmic actin filament
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