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GTP-binding protein 3D structures

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Line 7: Line 7:
**[[2eki]] – hGBP TGS domain – NMR – human<br />
**[[2eki]] – hGBP TGS domain – NMR – human<br />
 +
**[[6k1z]] – hGBP1<br />
 +
**[[7e58]] – hGBP2<br />
**[[3r7w]], [[4arz]] – yGtr1 + Gtr2 – yeast<br />
**[[3r7w]], [[4arz]] – yGtr1 + Gtr2 – yeast<br />
 +
**[[1ni3]] – fyYchF – fission yeast<br />
**[[3kxk]], [[3kxl]] – SsHflx (mutant) - ''Sulfolobus solfataricus''<br />
**[[3kxk]], [[3kxl]] – SsHflx (mutant) - ''Sulfolobus solfataricus''<br />
**[[2qtf]] – SsHflx<br />
**[[2qtf]] – SsHflx<br />
Line 18: Line 21:
**[[1wxq]] – GBP – ''Pyrococcus horikoshii''<br />
**[[1wxq]] – GBP – ''Pyrococcus horikoshii''<br />
**[[1yr6]] - PaGBP – ''Pyrococcus abyssi''<br />
**[[1yr6]] - PaGBP – ''Pyrococcus abyssi''<br />
-
**[[1ni3]] – YchF – ''Schizosaccharomyces pombe''<br />
 
**[[5oxf]], [[5owv]] – GBP – ''Campylobacter jejuni''<br />
**[[5oxf]], [[5owv]] – GBP – ''Campylobacter jejuni''<br />
Line 33: Line 35:
**[[2bc9]] - hGBP N terminal + GPPNHP<br />
**[[2bc9]] - hGBP N terminal + GPPNHP<br />
**[[2gao]] - hSar1A + GDP<br />
**[[2gao]] - hSar1A + GDP<br />
 +
**[[8dzo]], [[8dzt]], [[8e0d]], [[8e0h]] - hSar1A (mutant) + G4P<br />
 +
**[[8e0a]] - hSar1B + GDP<br />
**[[6eg8]] – hGBP subunits α-1,β-1,γ-2 + GDP<br />
**[[6eg8]] – hGBP subunits α-1,β-1,γ-2 + GDP<br />
**[[6au6]] – hGBP subunit α-1 + GDP<br />
**[[6au6]] – hGBP subunit α-1 + GDP<br />
 +
**[[6vkj]] – hGBP2 G domain + GDP<br />
 +
**[[7ckf]], [[7e5a]] – hGBP5 + GDP<br />
 +
**[[1git]], [[4aii]] - rRem2 G domain + GDP - rat<br />
**[[2fa9]] – ChSar1B (mutant) + GDP – Chinese hamster<br />
**[[2fa9]] – ChSar1B (mutant) + GDP – Chinese hamster<br />
**[[2fmx]] - ChSar1B + GDP<br />
**[[2fmx]] - ChSar1B + GDP<br />
**[[1yzn]] – yPt1 + GPPNHP<br />
**[[1yzn]] – yPt1 + GPPNHP<br />
 +
**[[7kmt]] – yPt1 in TRAPPII complex – Cryo EM<br />
**[[1ky2]] – yPt7 + GPPNHP<br />
**[[1ky2]] – yPt7 + GPPNHP<br />
**[[1ky3]] – yPt7 + GDP<br />
**[[1ky3]] – yPt7 + GDP<br />
Line 44: Line 52:
**[[4phf]] – yPt7 (mutant) + GDP<br />
**[[4phf]] – yPt7 (mutant) + GDP<br />
**[[3rwm]], [[3rwo]] – yPt32 + GPPNHP<br />
**[[3rwm]], [[3rwo]] – yPt32 + GPPNHP<br />
 +
**[[7e8t]], [[7ea3]], [[7u05]], [[7u06]] - yPt32 in TRAPPII complex – Cryo EM<br />
**[[1ek0]] – yPt51 + GPPNHP<br />
**[[1ek0]] – yPt51 + GPPNHP<br />
-
**[[2hjg]], [[4dcs]], [[4dct]], [[4dcu]], [[4dcv]], [[4kyu]], [[5mbs]] – BsEngA + GDP<br />
+
**[[6x90]] – ySar1 + Sec12<br />
 +
**[[8bsh]] – ySar1 + Sec23 + Sec24 – Cryo EM<br />
 +
**[[6zga]] – ySar1 + Sec23 + Sec24 + peptide – Cryo EM<br />
 +
**[[2hjg]], [[4dcs]], [[4dct]], [[4dcu]], [[4dcv]], [[5x4b]], [[5mbs]] – BsEngA + GDP<br />
**[[5m7h]] – BsEngA + GMPPNP<br />
**[[5m7h]] – BsEngA + GMPPNP<br />
**[[5x4b]] – BsEngA N-terminal + GDP<br />
**[[5x4b]] – BsEngA N-terminal + GDP<br />
Line 64: Line 76:
*GTP-binding protein complex with protein
*GTP-binding protein complex with protein
-
**[[6m8s]] – bGBP subunits β-1,γ-2 + KCTD12<br />
 
**[[6cmo]], [[6qno]] – hGBP subunits α-1,β-1,γ-t1 + antibody + rhodopsin – Cryo EM<br />
**[[6cmo]], [[6qno]] – hGBP subunits α-1,β-1,γ-t1 + antibody + rhodopsin – Cryo EM<br />
**[[6oij]], [[6oik]] – hGBP subunits α-1,β-1,γ-2 + antibody + AChR – Cryo EM<br />
**[[6oij]], [[6oik]] – hGBP subunits α-1,β-1,γ-2 + antibody + AChR – Cryo EM<br />
Line 82: Line 93:
**[[6kpf]], [[6kpg]] – hGBP subunits α-1,β-1,γ-2 + scFv + cannabinoid receptor – Cryo EM<br />
**[[6kpf]], [[6kpg]] – hGBP subunits α-1,β-1,γ-2 + scFv + cannabinoid receptor – Cryo EM<br />
**[[6lfm]], [[6lfo]] – hGBP subunits α-1,β-1,γ-2 + scFv + interleukin-8 + C-X-C chemokine receptor – Cryo EM<br />
**[[6lfm]], [[6lfo]] – hGBP subunits α-1,β-1,γ-2 + scFv + interleukin-8 + C-X-C chemokine receptor – Cryo EM<br />
 +
**[[6loj]] – hGBP1 + invasion plasmid antigen + GDP<br />
 +
**[[6m8s]] – bGBP subunits b-1, g-2 + KCTD12<br />
**[[6dde]], [[6ddf]] – bGBP subunits α-1,β-1,γ-2 + scFv + opioid receptor + DAMGO – Cryo EM<br />
**[[6dde]], [[6ddf]] – bGBP subunits α-1,β-1,γ-2 + scFv + opioid receptor + DAMGO – Cryo EM<br />
**[[6b20]] – bGBP subunits β-1,γ-t1 (mutant) + nanobody – bovine<br />
**[[6b20]] – bGBP subunits β-1,γ-t1 (mutant) + nanobody – bovine<br />
Line 94: Line 107:
**[[3cpj]] – yPt31 + Rab GDP-dissociation inhibitor<br />
**[[3cpj]] – yPt31 + Rab GDP-dissociation inhibitor<br />
**[[1m2o]] – ySar1 + protein transport protein sec23<br />
**[[1m2o]] – ySar1 + protein transport protein sec23<br />
 +
**[[2qtv]] - ySar1 + protein transport protein sec23 + GNP<br />
**[[6gni]] - ySar1 + protein transport protein sec23 + Sec24 + GNP<br />
**[[6gni]] - ySar1 + protein transport protein sec23 + Sec24 + GNP<br />
**[[6jwp]] – yGtr1 + Gtr2 + Meh1 + Ego2 + Slm4 + GNP<br />
**[[6jwp]] – yGtr1 + Gtr2 + Meh1 + Ego2 + Slm4 + GNP<br />
Line 137: Line 151:
**[[1x3s]] – hRab-18 + GPPNHP
**[[1x3s]] – hRab-18 + GPPNHP
**[[6huf]] - hRab-27A + GNP<br />
**[[6huf]] - hRab-27A + GNP<br />
 +
**[[7opp]], [[7opq]], [[7opr]] - hRab-27A/SLP2A + GNP<br />
**[[6ff8]] - hRab-32 + GTP<br />
**[[6ff8]] - hRab-32 + GTP<br />
**[[6hdu]], [[6s5h]] - hRab-38 + GTP<br />
**[[6hdu]], [[6s5h]] - hRab-38 + GTP<br />
Line 153: Line 168:
**[[6ba6]] – hRab-1B + talin-1<br />
**[[6ba6]] – hRab-1B + talin-1<br />
**[[4m8n]] – hRab-1B + plexin<br />
**[[4m8n]] – hRab-1B + plexin<br />
 +
**[[6kyk]], [[7c7i]] – hRab-1B + Shank3<br />
 +
**[[7c7j]] – hRab-1B (mutant) + Shank3<br />
 +
**[[6uzk]] – hRab-1B + KRIT1 + GNP<br />
**[[4dxa]] – hRab-1B (mutant) + KRIT1<br />
**[[4dxa]] – hRab-1B (mutant) + KRIT1<br />
**[[4hdq]], [[4hdo]] – hRab-1B + HEG1 + KRIT1<br />
**[[4hdq]], [[4hdo]] – hRab-1B + HEG1 + KRIT1<br />
Line 170: Line 188:
**[[6ehr]], [[5x6v]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5<br />
**[[6ehr]], [[5x6v]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5<br />
**[[6u62]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5 + GTP + GDP – Cryo EM<br />
**[[6u62]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5 + GTP + GDP – Cryo EM<br />
 +
**[[7uxc]] – hRag-A + hRag-C in MtorC1-TFEB-RAG-ragulator complex + GTP + GDP – Cryo EM<br />
 +
**[[8dhb]] – hRag-A + hRag-C in FLCN-Gap complex – Cryo EM<br />
**[[6wj2]], [[6wj3]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5 + GDP – Cryo EM<br />
**[[6wj2]], [[6wj3]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5 + GDP – Cryo EM<br />
**[[6nzd]], [[6ulg]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5 + folliculin + folliculin-interacting protein + GDP – Cryo EM<br />
**[[6nzd]], [[6ulg]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5 + folliculin + folliculin-interacting protein + GDP – Cryo EM<br />
**[[6sb2]] – hRag-A + hRag-C + Mtor + Torc + Raptor + GDP + GTP – Cryo EM<br />
**[[6sb2]] – hRag-A + hRag-C + Mtor + Torc + Raptor + GDP + GTP – Cryo EM<br />
 +
**[[7t3a]], [[7t3b]], [[7t3c]] – hRag-A + hRag-C in GATOR1-RAG-Ragulator complex – Cryo EM<br />
 +
**[[7ux2]] – hRag-A + hRag-C in RAPTOR-TFEB1-RAG-Ragulator complex – Cryo EM<br />
 +
**[[7uxh]] – hRag-A + hRag-C in TORC1-TFEB1-RAG-Ragulator complex – Cryo EM<br />
**[[6sb0]] – hRag-A + hRag-C + Mtor + Torc + Raptor + Pro-rich Akt1 substrate + GDP + GTP – Cryo EM<br />
**[[6sb0]] – hRag-A + hRag-C + Mtor + Torc + Raptor + Pro-rich Akt1 substrate + GDP + GTP – Cryo EM<br />
**[[6oq3]], [[6oq4]] – hRap-1B + krev interacting trapped protein + GNP<br />
**[[6oq3]], [[6oq4]] – hRap-1B + krev interacting trapped protein + GNP<br />
Line 188: Line 211:
**[[4x0r]] – hMx2 stalk region (mutant)<br />
**[[4x0r]] – hMx2 stalk region (mutant)<br />
**[[4whj]] – hMx2 residues 84-715 (mutant)<br />
**[[4whj]] – hMx2 residues 84-715 (mutant)<br />
 +
**[[5uot]] – hMxB – Cryo EM<br />
*'''Rho-related small GTP-binding protein'''
*'''Rho-related small GTP-binding protein'''
Line 205: Line 229:
**[[1m7b]] - hRhoE + GTP<br />
**[[1m7b]] - hRhoE + GTP<br />
**[[1gwn]] - mRhoE + GTP <br />
**[[1gwn]] - mRhoE + GTP <br />
 +
**[[8etd]] – fyRho1 + GDP <br />
*Rho-related small GTP-binding protein complex with protein
*Rho-related small GTP-binding protein complex with protein
**[[2v55]] – hRhoE + Rho-associated protein kinase<br />
**[[2v55]] – hRhoE + Rho-associated protein kinase<br />
 +
**[[8b2k]] – hRhoE + 14-3-3 protein<br />
**[[3q3j]] – hRho6 + plexin-A2 nucleotide-binding domain<br />
**[[3q3j]] – hRho6 + plexin-A2 nucleotide-binding domain<br />
**[[2rex]] – hRho6 + plexin-B1<br />
**[[2rex]] – hRho6 + plexin-B1<br />
 +
**[[7kdc]] - hRhoD + plexin-B2 + GNP<br />
**[[1cc0]] – hRhoA + GDP-dissociation inhibitor + GDP<br />
**[[1cc0]] – hRhoA + GDP-dissociation inhibitor + GDP<br />
**[[6bca]] - hRhoA + kinase anchor protein + GTP<br />
**[[6bca]] - hRhoA + kinase anchor protein + GTP<br />
**[[6sge]] - hRhoB + nanobody + GTP<br />
**[[6sge]] - hRhoB + nanobody + GTP<br />
**[[6uka]] - hRhoG + ELMO + GNP<br />
**[[6uka]] - hRhoG + ELMO + GNP<br />
 +
**[[7y4a]] - hRhoG + ELMO + GDP<br />
**[[3a58]] – yRho1 (mutant) + exocyst complex component Sec3 + cancidas<br />
**[[3a58]] – yRho1 (mutant) + exocyst complex component Sec3 + cancidas<br />
Line 290: Line 318:
**[[6bt0]], [[6bsx]] - hRheb + GDP + inhibitor<br />
**[[6bt0]], [[6bsx]] - hRheb + GDP + inhibitor<br />
**[[3t5g]] – hRheb + GMP-PDE delta<br />
**[[3t5g]] – hRheb + GMP-PDE delta<br />
 +
**[[6bcu]] – hRheb + mTORC1 – Cryo EM<br />
**[[4o25]] – mRheb + GTP - mouse<br />
**[[4o25]] – mRheb + GTP - mouse<br />
**[[4o2l]] - mRheb (mutant) + GTP <br />
**[[4o2l]] - mRheb (mutant) + GTP <br />
Line 390: Line 419:
**[[2l0x]] – rRheb + GDP<br />
**[[2l0x]] – rRheb + GDP<br />
 +
*Nucleolar GTP-binding protein 1
 +
 +
**[[7o9k]], [[7o9m]], [[7odt]], [[7of2]], [[7of4]], [[7of6]], [[7of7]], [[7oi6]], [[7pd3]] – hNGBP 1 in 39S mitoribosome – Cryo EM<br />
 +
**[[6lss]], [[6lu8]] – hNGBP 1 in 60S ribosome – Cryo EM<br />
 +
**[[3jct]], [[4v7f]], [[5jcs]], [[6c0f]], [[6elz]], [[6em1]], [[6em5]], [[6m62]], [[6n8l]], [[6ylg]], [[6ylh]], [[6ylx]], [[6yly]], [[7bt6]], [[7btb]], [[7nac]], [[7naf]], [[7of1]], [[7oh3]], [[7ohp]], [[7ohq]], [[7ohr]], [[7ohs]], [[7oht]], [[7ohv]], [[7ohw]], [[7ohx]], [[7ohy]], [[7r7a]], [[7r7c]], [[7u0h]], [[7ug6]], [[7uoo]], [[7uqb]], [[7uqz]], [[7uui]], [[7z34]], [[8hfr]] – yNGBP 1 in pre-60S ribosome – Cryo EM<br />
 +
**[[7nrc]] – yNGBP 1 in 80S ribosome – Cryo EM<br />
 +
**[[8esq]], [[8etc]], [[8etg]], [[8eth]], [[8eti]], [[8etj]], [[8eup]], [[8euy]], [[8ev3]] – fyNGBP 1 in 60S ribosome – Cryo EM<br />
 +
**[[4csu]], [[5ady]], [[5zzm]], [[7bl2]], [[7bl3]], [[7bl4]], [[7bl5]], [[7bl6]], [[7yla]] – EcNGBP 1 in pre-50S ribosome – Cryo EM<br />
 +
**[[5aa0]] – TtNGBP 1 in 50S ribosome – Cryo EM<br />
 +
**[[6yxx]] – NGBP 1 in 12S mitoribosome – Trypanosoma brucei - Cryo EM<br />
 +
**[[8a57]] – NGBP in 50S ribosome – Listeria monocytogenes - Cryo EM<br />
*'''Small GTPase h-Ras''' see [[GTPase HRas]]
*'''Small GTPase h-Ras''' see [[GTPase HRas]]

Current revision

3D Structures of GTP-binding protein

Updated on 23-April-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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