1hi4

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(New page: 200px<br /> <applet load="1hi4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hi4, resolution 1.80&Aring;" /> '''EOSINOPHIL-DERIVED ...)
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[[Image:1hi4.gif|left|200px]]<br />
 
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<applet load="1hi4" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1hi4, resolution 1.80&Aring;" />
 
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'''EOSINOPHIL-DERIVED NEUROTOXIN (EDN)-ADENOSINE-3'-5'-DIPHOSPHATE COMPLEX'''<br />
 
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==Overview==
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==Eosinophil-derived Neurotoxin (EDN) - Adenosien-3'-5'-Diphosphate Complex==
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Eosinophil-derived neurotoxin (EDN), a basic ribonuclease found in the, large specific granules of eosinophils, belongs to the pancreatic RNase A, family. Although its physiological function is still unclear, it has been, shown that EDN is a neurotoxin capable of inducing the Gordon phenomenon, in rabbits. EDN is also a potent helminthotoxin and can mediate antiviral, activity of eosinophils against isolated virions of the respiratory, syncytial virus. EDN is a catalytically efficient RNase sharing similar, substrate specificity with pancreatic RNase A with its ribonucleolytic, activity being absolutely essential for its neurotoxic, helminthotoxic, and antiviral activities. The crystal structure of recombinant human EDN, in the unliganded form has been determined previously (Mosimann, S. ... [[http://ispc.weizmann.ac.il/pmbin/getpm?11154698 (full description)]]
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<StructureSection load='1hi4' size='340' side='right'caption='[[1hi4]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1hi4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HI4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HI4 FirstGlance]. <br>
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1HI4 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with A3P as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1HI4 OCA]].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hi4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hi4 OCA], [https://pdbe.org/1hi4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hi4 RCSB], [https://www.ebi.ac.uk/pdbsum/1hi4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hi4 ProSAT]</span></td></tr>
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Mapping the ribonucleolytic active site of eosinophil-derived neurotoxin (EDN). High resolution crystal structures of EDN complexes with adenylic nucleotide inhibitors., Leonidas DD, Boix E, Prill R, Suzuki M, Turton R, Minson K, Swaminathan GJ, Youle RJ, Acharya KR, J Biol Chem. 2001 May 4;276(18):15009-17. Epub 2001 Jan 11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11154698 11154698]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RNAS2_HUMAN RNAS2_HUMAN] This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.<ref>PMID:3458170</ref> <ref>PMID:12578357</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hi/1hi4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hi4 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Acharya, K.R.]]
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[[Category: Acharya KR]]
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[[Category: Boix, E.]]
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[[Category: Boix E]]
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[[Category: Leonidas, D.D.]]
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[[Category: Leonidas DD]]
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[[Category: Minson, K.]]
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[[Category: Minson K]]
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[[Category: Prill, R.]]
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[[Category: Prill R]]
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[[Category: Suzuki, M.]]
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[[Category: Suzuki M]]
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[[Category: Swaminathan, G.J.]]
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[[Category: Swaminathan GJ]]
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[[Category: Turton, R.]]
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[[Category: Turton R]]
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[[Category: Youle, R.J.]]
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[[Category: Youle RJ]]
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[[Category: A3P]]
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[[Category: ribonuclease]]
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[[Category: rnase us]]
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[[Category: rnase-2]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 18:01:23 2007''
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Current revision

Eosinophil-derived Neurotoxin (EDN) - Adenosien-3'-5'-Diphosphate Complex

PDB ID 1hi4

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