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7rec

From Proteopedia

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Current revision (16:29, 18 October 2023) (edit) (undo)
 
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<StructureSection load='7rec' size='340' side='right'caption='[[7rec]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='7rec' size='340' side='right'caption='[[7rec]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7rec]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7REC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7REC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7rec]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7REC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7REC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7ZV:5-HYDROXYDICLOFENAC'>7ZV</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CAMK2A, CAMKA, KIAA0968 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7ZV:5-HYDROXYDICLOFENAC'>7ZV</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rec OCA], [https://pdbe.org/7rec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rec RCSB], [https://www.ebi.ac.uk/pdbsum/7rec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rec ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rec OCA], [https://pdbe.org/7rec PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rec RCSB], [https://www.ebi.ac.uk/pdbsum/7rec PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rec ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/KCC2A_HUMAN KCC2A_HUMAN]] CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
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[https://www.uniprot.org/uniprot/KCC2A_HUMAN KCC2A_HUMAN] CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7rec" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7rec" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Calcium/calmodulin dependent protein kinase 3D structures|Calcium/calmodulin dependent protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chi, C C]]
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[[Category: Chi CC]]
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[[Category: Gee, C L]]
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[[Category: Gee CL]]
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[[Category: Kuriyan, J]]
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[[Category: Kuriyan J]]
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[[Category: McSpadden, E D]]
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[[Category: McSpadden ED]]
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[[Category: Camkii hub]]
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[[Category: Oligomer]]
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[[Category: Signaling protein]]
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Current revision

Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human CaMKII alpha hub bound to 5-HDC

PDB ID 7rec

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OCA

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