1nix

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==THREE DIMENSIONAL SOLUTION STRUCTURE OF HAINANTOXIN-I BY 2D 1H-NMR==
==THREE DIMENSIONAL SOLUTION STRUCTURE OF HAINANTOXIN-I BY 2D 1H-NMR==
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<StructureSection load='1nix' size='340' side='right'caption='[[1nix]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1nix' size='340' side='right'caption='[[1nix]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1nix]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ornithoctonus_hainana Ornithoctonus hainana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NIX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1nix]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haplopelma_hainanum Haplopelma hainanum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NIX FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nix OCA], [https://pdbe.org/1nix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nix RCSB], [https://www.ebi.ac.uk/pdbsum/1nix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nix ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nix OCA], [https://pdbe.org/1nix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nix RCSB], [https://www.ebi.ac.uk/pdbsum/1nix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nix ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/H1A01_CYRHA H1A01_CYRHA] Weakly blocks the rat SCN2A/SCN1B (Nav1.2/beta-1) sodium channel (IC(50)=68 uM) and the insect sodium channel para/tipE (IC(50)=4.3 uM), without altering the activation or inactivation kinetics (depressant toxin).<ref>PMID:14675784</ref> <ref>PMID:26429937</ref>
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Haplopelma hainanum]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ornithoctonus hainana]]
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[[Category: Li D]]
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[[Category: Li, D]]
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[[Category: Liang S]]
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[[Category: Liang, S]]
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[[Category: Inhibitor cystine knot motif]]
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[[Category: Toxin]]
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THREE DIMENSIONAL SOLUTION STRUCTURE OF HAINANTOXIN-I BY 2D 1H-NMR

PDB ID 1nix

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