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7vaf
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7vaf is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of Rat NTCP complexed with YN69202Fab== | |
| - | + | <StructureSection load='7vaf' size='340' side='right'caption='[[7vaf]], [[Resolution|resolution]] 3.11Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7vaf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VAF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VAF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vaf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vaf OCA], [https://pdbe.org/7vaf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vaf RCSB], [https://www.ebi.ac.uk/pdbsum/7vaf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vaf ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/NTCP_RAT NTCP_RAT]] As a major transporter of conjugated bile salts from plasma into the hepatocyte, it has a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins. It exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium. Able to transport taurocholate, cholate, and the non-bile acid estron sulfate.[UniProtKB:Q14973] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Asami J]] | ||
| + | [[Category: Ohto U]] | ||
| + | [[Category: Shimizu T]] | ||
Current revision
Cryo-EM structure of Rat NTCP complexed with YN69202Fab
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