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5bkf
From Proteopedia
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| - | ==== | + | ==Cyro-EM structure of human Glycine Receptor alpha2-beta heteromer, Glycine bound, desensitized state== |
| - | <StructureSection load='5bkf' size='340' side='right'caption='[[5bkf]]' scene=''> | + | <StructureSection load='5bkf' size='340' side='right'caption='[[5bkf]], [[Resolution|resolution]] 3.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5bkf]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BKF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BKF FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bkf OCA], [https://pdbe.org/5bkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bkf RCSB], [https://www.ebi.ac.uk/pdbsum/5bkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bkf ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bkf OCA], [https://pdbe.org/5bkf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bkf RCSB], [https://www.ebi.ac.uk/pdbsum/5bkf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bkf ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/GLRA2_HUMAN GLRA2_HUMAN] The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GLRA2_HUMAN GLRA2_HUMAN] Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488, PubMed:26370147). Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677). Plays a role in synaptic plasticity (By similarity). Contributes to the generation of inhibitory postsynaptic currents, and is involved in the down-regulation of neuronal excitability (PubMed:25445488). Plays a role in cellular responses to ethanol (PubMed:23895467).[UniProtKB:Q7TNC8]<ref>PMID:15302677</ref> <ref>PMID:16144831</ref> <ref>PMID:2155780</ref> <ref>PMID:23895467</ref> <ref>PMID:25445488</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Green Fluorescent Protein 3D structures|Green Fluorescent Protein 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Aequorea victoria]] | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Wang W]] |
| + | [[Category: Yu H]] | ||
Current revision
Cyro-EM structure of human Glycine Receptor alpha2-beta heteromer, Glycine bound, desensitized state
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