7ddu
From Proteopedia
(Difference between revisions)
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==Elephant seal myoglobin esMb== | ==Elephant seal myoglobin esMb== | ||
| - | <StructureSection load='7ddu' size='340' side='right'caption='[[7ddu]]' scene=''> | + | <StructureSection load='7ddu' size='340' side='right'caption='[[7ddu]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DDU FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7ddu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mirounga_angustirostris Mirounga angustirostris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DDU FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ddu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ddu OCA], [https://pdbe.org/7ddu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ddu RCSB], [https://www.ebi.ac.uk/pdbsum/7ddu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ddu ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ddu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ddu OCA], [https://pdbe.org/7ddu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ddu RCSB], [https://www.ebi.ac.uk/pdbsum/7ddu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ddu ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/R9S002_MIRAN R9S002_MIRAN] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.[ARBA:ARBA00002755][RuleBase:RU251113] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Myoglobin (Mb) is highly concentrated in the myocytes of diving mammals such as whales and seals, in comparison with land animals, and its molecular evolution has played a crucial role in their deep-sea adaptation. We previously resurrected ancestral whale Mbs and demonstrated the evolutional strategies for higher solubility under macromolecular crowding conditions. Pinnipeds, such as seals and sea lions, are also expert diving mammals with Mb-rich muscles. In the present study, we resurrected ancestral pinniped Mbs and investigated their biochemical and structural properties. Comparisons between pinniped and whale Mbs revealed the common and distinctive strategies for the deep-sea adaptation. The overall evolution processes, gaining precipitant tolerance and improving thermodynamic stability, were commonly observed. However, the strategies for improving the folding stability differed, and the pinniped Mbs exploited the shielding of hydrophobic surfaces more effectively than the whale Mbs. | ||
| + | |||
| + | Common and unique strategies of myoglobin evolution for deep-sea adaptation of diving mammals.,Isogai Y, Imamura H, Nakae S, Sumi T, Takahashi KI, Shirai T iScience. 2021 Jul 30;24(8):102920. doi: 10.1016/j.isci.2021.102920. eCollection , 2021 Aug 20. PMID:34430810<ref>PMID:34430810</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7ddu" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Myoglobin 3D structures|Myoglobin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Mirounga angustirostris]] | ||
[[Category: Imamura H]] | [[Category: Imamura H]] | ||
[[Category: Isogai Y]] | [[Category: Isogai Y]] | ||
Current revision
Elephant seal myoglobin esMb
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