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1oo3
From Proteopedia
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==P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of PI3-Kinase== | ==P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of PI3-Kinase== | ||
| - | <StructureSection load='1oo3' size='340' side='right'caption='[[1oo3 | + | <StructureSection load='1oo3' size='340' side='right'caption='[[1oo3]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1oo3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1oo3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OO3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OO3 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oo3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oo3 OCA], [https://pdbe.org/1oo3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oo3 RCSB], [https://www.ebi.ac.uk/pdbsum/1oo3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oo3 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oo3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oo3 OCA], [https://pdbe.org/1oo3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oo3 RCSB], [https://www.ebi.ac.uk/pdbsum/1oo3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oo3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/P85A_BOVIN P85A_BOVIN] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity). | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Bos taurus]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Guenther | + | [[Category: Guenther UL]] |
| - | [[Category: Schaffhausen | + | [[Category: Schaffhausen B]] |
| - | [[Category: Weyrauch | + | [[Category: Weyrauch B]] |
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Current revision
P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of PI3-Kinase
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