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1pa0

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<StructureSection load='1pa0' size='340' side='right'caption='[[1pa0]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='1pa0' size='340' side='right'caption='[[1pa0]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1pa0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bothrops_neuwiedi_pauloensis Bothrops neuwiedi pauloensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PA0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1pa0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bothrops_pauloensis Bothrops pauloensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PA0 FirstGlance]. <br>
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pa0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pa0 OCA], [https://pdbe.org/1pa0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pa0 RCSB], [https://www.ebi.ac.uk/pdbsum/1pa0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pa0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pa0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pa0 OCA], [https://pdbe.org/1pa0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pa0 RCSB], [https://www.ebi.ac.uk/pdbsum/1pa0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pa0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PA2H_BOTPA PA2H_BOTPA]] Snake venom phospholipase A2 (PLA2) that lacks enzymatic activity. Is myotoxic. Displays bactericidal activity and promotes the blockage of the neuromuscular contraction of the chick biventer cervicis muscle. Also disrupts artificial membranes, and provokes tissue damages characterized by edema, necrosis and inflammation. May act as pro-inflammatory mediators, inducing metalloproteinase and cytokine production from the inflammatory and satellite cells.<ref>PMID:10860537</ref> <ref>PMID:9972319</ref> <ref>PMID:14623331</ref>
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[https://www.uniprot.org/uniprot/PA2H_BOTPA PA2H_BOTPA] Snake venom phospholipase A2 (PLA2) that lacks enzymatic activity. Is myotoxic. Displays bactericidal activity and promotes the blockage of the neuromuscular contraction of the chick biventer cervicis muscle. Also disrupts artificial membranes, and provokes tissue damages characterized by edema, necrosis and inflammation. May act as pro-inflammatory mediators, inducing metalloproteinase and cytokine production from the inflammatory and satellite cells.<ref>PMID:10860537</ref> <ref>PMID:9972319</ref> <ref>PMID:14623331</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pa/1pa0_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pa/1pa0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bothrops neuwiedi pauloensis]]
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[[Category: Bothrops pauloensis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Fontes, M R]]
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[[Category: Fontes MR]]
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[[Category: Giglio, J R]]
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[[Category: Giglio JR]]
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[[Category: Magro, A J]]
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[[Category: Magro AJ]]
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[[Category: Soares, A M]]
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[[Category: Soares AM]]
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[[Category: Bothropic venom]]
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[[Category: Hydrolase]]
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[[Category: Lys49-phospholipase a2]]
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[[Category: Myotoxin]]
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Current revision

CRYSTAL STRUCTURE OF BNSP-7, A LYS49-PHOSPHOLIPASE A2

PDB ID 1pa0

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