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7ve0
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Ritonavir bound Plasmepsin II (PMII) from Plasmodium falciparum== | |
| + | <StructureSection load='7ve0' size='340' side='right'caption='[[7ve0]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7ve0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VE0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VE0 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RIT:RITONAVIR'>RIT</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ve0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ve0 OCA], [https://pdbe.org/7ve0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ve0 RCSB], [https://www.ebi.ac.uk/pdbsum/7ve0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ve0 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PLM2_PLAF7 PLM2_PLAF7] During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation (PubMed:29943906). May cleave preferentially denatured hemoglobin that has been cleaved by PMI (By similarity). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).[UniProtKB:P46925]<ref>PMID:29943906</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Plasmepsin|Plasmepsin]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Plasmodium falciparum 3D7]] | ||
| + | [[Category: Bhaumik P]] | ||
| + | [[Category: Mishra V]] | ||
| + | [[Category: Rathore I]] | ||
Current revision
Crystal Structure of Ritonavir bound Plasmepsin II (PMII) from Plasmodium falciparum
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