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7ont

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==PARP1 catalytic domain in complex with a selective pyridine carboxamide-based inhibitor (compound 22)==
==PARP1 catalytic domain in complex with a selective pyridine carboxamide-based inhibitor (compound 22)==
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<StructureSection load='7ont' size='340' side='right'caption='[[7ont]]' scene=''>
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<StructureSection load='7ont' size='340' side='right'caption='[[7ont]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ONT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ONT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7ont]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ONT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ONT FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ont FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ont OCA], [https://pdbe.org/7ont PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ont RCSB], [https://www.ebi.ac.uk/pdbsum/7ont PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ont ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.853&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VKQ:5-[4-[(3-ethyl-2-oxidanylidene-1~{H}-quinolin-7-yl)methyl]piperazin-1-yl]-~{N}-methyl-pyridine-2-carboxamide'>VKQ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ont FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ont OCA], [https://pdbe.org/7ont PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ont RCSB], [https://www.ebi.ac.uk/pdbsum/7ont PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ont ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>
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==See Also==
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*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Balazs A]]
[[Category: Balazs A]]

Current revision

PARP1 catalytic domain in complex with a selective pyridine carboxamide-based inhibitor (compound 22)

PDB ID 7ont

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