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6vsv

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Current revision (08:18, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6vsv' size='340' side='right'caption='[[6vsv]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
<StructureSection load='6vsv' size='340' side='right'caption='[[6vsv]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6vsv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VSV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6vsv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VSV FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SCN4B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vsv OCA], [https://pdbe.org/6vsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vsv RCSB], [https://www.ebi.ac.uk/pdbsum/6vsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vsv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vsv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vsv OCA], [https://pdbe.org/6vsv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vsv RCSB], [https://www.ebi.ac.uk/pdbsum/6vsv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vsv ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/SCN4B_HUMAN SCN4B_HUMAN]] Romano-Ward syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/SCN4B_HUMAN SCN4B_HUMAN] Romano-Ward syndrome. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SCN4B_HUMAN SCN4B_HUMAN]] Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation (By similarity).
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[https://www.uniprot.org/uniprot/SCN4B_HUMAN SCN4B_HUMAN] Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Das, S]]
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[[Category: Das S]]
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[[Category: Petegem, F Van]]
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[[Category: Van Petegem F]]
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[[Category: Beta4 subunit]]
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[[Category: Disease mutant]]
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[[Category: Membrane protein]]
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[[Category: Sodium channel]]
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Current revision

Crystal structure of a disease mutant of the Voltage-gated Sodium Channel Beta 4 subunit extracellular domain

PDB ID 6vsv

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OCA

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