1f84

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[[Image:1f84.gif|left|200px]]
 
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==SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIID==
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The line below this paragraph, containing "STRUCTURE_1f84", creates the "Structure Box" on the page.
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<StructureSection load='1f84' size='340' side='right'caption='[[1f84]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1f84]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F84 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1F84 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1f84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f84 OCA], [https://pdbe.org/1f84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1f84 RCSB], [https://www.ebi.ac.uk/pdbsum/1f84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1f84 ProSAT]</span></td></tr>
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{{STRUCTURE_1f84| PDB=1f84 | SCENE= }}
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</table>
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<div style="background-color:#fffaf0;">
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'''SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIID'''
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== Publication Abstract from PubMed ==
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==Overview==
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Translation of the hepatitis C virus (HCV) polyprotein is initiated at an internal ribosome entry site (IRES) element in the 5' untranslated region of HCV RNA. The HCV IRES element interacts directly with the 40S subunit, and biochemical experiments have implicated RNA elements near the AUG start codon as required for IRES-40S subunit complex formation. The data we present here show that two RNA stem loops, domains IIId and IIIe, are involved in IRES-40S subunit interaction. The structures of the two RNA domains were solved by NMR spectroscopy and reveal structural features that may explain their role in IRES function.
Translation of the hepatitis C virus (HCV) polyprotein is initiated at an internal ribosome entry site (IRES) element in the 5' untranslated region of HCV RNA. The HCV IRES element interacts directly with the 40S subunit, and biochemical experiments have implicated RNA elements near the AUG start codon as required for IRES-40S subunit complex formation. The data we present here show that two RNA stem loops, domains IIId and IIIe, are involved in IRES-40S subunit interaction. The structures of the two RNA domains were solved by NMR spectroscopy and reveal structural features that may explain their role in IRES function.
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==About this Structure==
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Structures of two RNA domains essential for hepatitis C virus internal ribosome entry site function.,Lukavsky PJ, Otto GA, Lancaster AM, Sarnow P, Puglisi JD Nat Struct Biol. 2000 Dec;7(12):1105-10. PMID:11101890<ref>PMID:11101890</ref>
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F84 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structures of two RNA domains essential for hepatitis C virus internal ribosome entry site function., Lukavsky PJ, Otto GA, Lancaster AM, Sarnow P, Puglisi JD, Nat Struct Biol. 2000 Dec;7(12):1105-10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11101890 11101890]
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</div>
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[[Category: Lancaster, A M.]]
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<div class="pdbe-citations 1f84" style="background-color:#fffaf0;"></div>
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[[Category: Lukavsky, P J.]]
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== References ==
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[[Category: Otto, G A.]]
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<references/>
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[[Category: Puglisi, J D.]]
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__TOC__
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[[Category: Sarnow, P.]]
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</StructureSection>
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[[Category: Hairpin loop]]
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[[Category: Large Structures]]
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[[Category: Hepatitis c virus internal ribosome entry site]]
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[[Category: Lancaster AM]]
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[[Category: Loop e motif]]
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[[Category: Lukavsky PJ]]
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[[Category: Ribonucleic acid]]
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[[Category: Otto GA]]
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[[Category: Rna structure]]
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[[Category: Puglisi JD]]
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[[Category: Sarcin/ricin loop]]
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[[Category: Sarnow P]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:00:54 2008''
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Current revision

SOLUTION STRUCTURE OF HCV IRES RNA DOMAIN IIID

PDB ID 1f84

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