1qrp
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1qrp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QRP FirstGlance]. <br> | <table><tr><td colspan='2'>[[1qrp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QRP FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HH0:METHYL+N-[(2S)-2-({(S)-HYDROXY[(1R)-3-METHYL-1-{[N-(3-METHYLBUTANOYL)-L-VALYL-L-VALYL]AMINO}BUTYL]PHOSPHORYL}OXY)-3-PHENYLPROPANOYL]-L-ALANYL-L-ALANINATE'>HH0</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HH0:METHYL+N-[(2S)-2-({(S)-HYDROXY[(1R)-3-METHYL-1-{[N-(3-METHYLBUTANOYL)-L-VALYL-L-VALYL]AMINO}BUTYL]PHOSPHORYL}OXY)-3-PHENYLPROPANOYL]-L-ALANYL-L-ALANINATE'>HH0</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qrp OCA], [https://pdbe.org/1qrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qrp RCSB], [https://www.ebi.ac.uk/pdbsum/1qrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qrp ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qrp OCA], [https://pdbe.org/1qrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qrp RCSB], [https://www.ebi.ac.uk/pdbsum/1qrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qrp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PEPA4_HUMAN PEPA4_HUMAN] Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qr/1qrp_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qr/1qrp_consurf.spt"</scriptWhenChecked> | ||
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Bartlett | + | [[Category: Bartlett PA]] |
| - | [[Category: Cherney | + | [[Category: Cherney MM]] |
| - | [[Category: Fujinaga | + | [[Category: Fujinaga M]] |
| - | [[Category: Hanson | + | [[Category: Hanson JE]] |
| - | [[Category: James | + | [[Category: James MNG]] |
| - | [[Category: Tarasova | + | [[Category: Tarasova NI]] |
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Current revision
Human pepsin 3A in complex with a phosphonate inhibitor IVA-VAL-VAL-LEU(P)-(O)PHE-ALA-ALA-OME
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