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Histone methyltransferase 3D structures
From Proteopedia
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== 3D Structures of histone methyltransferase == | == 3D Structures of histone methyltransferase == | ||
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**[[2igq]] – hHMT-1 C terminal | **[[2igq]] – hHMT-1 C terminal | ||
| - | *Histone-lysine N-methyltransferase; Domains – Tudor 190-410 | + | *Histone-lysine N-methyltransferase; Domains – Tudor 190-410; CxxC or zinc finger 1146-1214 |
**[[3s8s]] – hKHMT SETD1A RRM domain<br /> | **[[3s8s]] – hKHMT SETD1A RRM domain<br /> | ||
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**[[1h3i]] - hKHMT SET7/9 residues 52-344<br /> | **[[1h3i]] - hKHMT SET7/9 residues 52-344<br /> | ||
**[[2o8j]] - hKHMT H3K9 residues 913-1193<br /> | **[[2o8j]] - hKHMT H3K9 residues 913-1193<br /> | ||
| + | **[[2j2s]] – Mll1 CxxC domain - NMR<br /> | ||
**[[5f5e]] – Mll1 residues 3813-3969<br /> | **[[5f5e]] – Mll1 residues 3813-3969<br /> | ||
**[[5f59]] – Mll3 residues 4757-4910<br /> | **[[5f59]] – Mll3 residues 4757-4910<br /> | ||
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**[[2j8a]] – KHMT SET1 RRM domain – yeast<br /> | **[[2j8a]] – KHMT SET1 RRM domain – yeast<br /> | ||
**[[1u2z]] – yKHMT C terminal<br /> | **[[1u2z]] – yKHMT C terminal<br /> | ||
| + | **[[5h6z]], [[5ww0]] - KHMT SET7 – fission yeast <br /> | ||
**[[1ml9]] – NcKHMT Dim-5 – ''Neurospora crassa''<br /> | **[[1ml9]] – NcKHMT Dim-5 – ''Neurospora crassa''<br /> | ||
**[[1n3j]] – PvKHMT – Paramecium bursaria chlorella virus<br /> | **[[1n3j]] – PvKHMT – Paramecium bursaria chlorella virus<br /> | ||
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**[[5ex3]], [[5ex0]] - hKHMT Smyd3 + peptide<br /> | **[[5ex3]], [[5ex0]] - hKHMT Smyd3 + peptide<br /> | ||
**[[5yvx]] - hKHMT Ashh2 CW domain + H3 peptide<br /> | **[[5yvx]] - hKHMT Ashh2 CW domain + H3 peptide<br /> | ||
| - | ** | + | **[[6qxz]] - hKHMT Ashh2 CW domain + H3 peptide - NMR<br /> |
**[[4l58]] - hKHMT PHD-type zinc finger domain + H3 peptide<br /> | **[[4l58]] - hKHMT PHD-type zinc finger domain + H3 peptide<br /> | ||
**[[6cko]] - zKHMT + AF-10 - zebrafish<br /> | **[[6cko]] - zKHMT + AF-10 - zebrafish<br /> | ||
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**[[3vuz]], [[3vv0]] - hKHMT SET7/9 SET domain + deoxyadenosine derivative<br /> | **[[3vuz]], [[3vv0]] - hKHMT SET7/9 SET domain + deoxyadenosine derivative<br /> | ||
**[[4x8p]], [[4x8n]] – hKHMT Ash2L Spry domain + RBBP5 <br /> | **[[4x8p]], [[4x8n]] – hKHMT Ash2L Spry domain + RBBP5 <br /> | ||
| - | **[[6e2h]] – hKHMT SET/Ash2 + DPY-30L <br /> | + | **[[4riq]], [[6e2h]] – hKHMT SET/Ash2 + DPY-30L <br /> |
**[[6u4y]] - hKHMT Ezh2 + polycomb protein EED<br /> | **[[6u4y]] - hKHMT Ezh2 + polycomb protein EED<br /> | ||
**[[6jn2]] – hKHMT4 coiled-coil domain 470-550 + AF-10<br /> | **[[6jn2]] – hKHMT4 coiled-coil domain 470-550 + AF-10<br /> | ||
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**[[6cen]] - hKHMT Nsd3 + inhibitor peptide + SAM<br /> | **[[6cen]] - hKHMT Nsd3 + inhibitor peptide + SAM<br /> | ||
**[[7bre]] – hKHMT Mll1 + RBBP5 + Ash2L<br /> | **[[7bre]] – hKHMT Mll1 + RBBP5 + Ash2L<br /> | ||
| - | **[[5f6l]] – hKHMT Mll1 (mutant) + RBBP5 + Ash2L<br /> | + | **[[5f6l]], [[7w67]], [[7w6a]], [[7w6i]], [[7w6j]] – hKHMT Mll1 (mutant) + RBBP5 + Ash2L<br /> |
**[[5f6k]] – hKHMT Mll3 + RBBP5 + Ash2L + peptide<br /> | **[[5f6k]] – hKHMT Mll3 + RBBP5 + Ash2L + peptide<br /> | ||
**[[1peg]] - NcKHMT Dim-5 + SAH + H3 peptide<br /> | **[[1peg]] - NcKHMT Dim-5 + SAH + H3 peptide<br /> | ||
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**[[7crr]] - hKHMT Nsd3 in nucleosome – Cryo EM<br /> | **[[7crr]] - hKHMT Nsd3 in nucleosome – Cryo EM<br /> | ||
**[[7crp]], [[7crq]] - hKHMT Nsd3 (mutant) in nucleosome – Cryo EM<br /> | **[[7crp]], [[7crq]] - hKHMT Nsd3 (mutant) in nucleosome – Cryo EM<br /> | ||
| + | **[[6w5i]], [[6w5m]], [[6w5n]] – hKHMT Ash2L in nucleosome – Cryo EM<br /> | ||
| + | **[[7xpx]] – hKHMT SET8 in nucleosome – Cryo EM<br /> | ||
| + | **[[7mbm]], [[7mbn]], [[7ud5]] – hKHMT MLL1 in nucleosome – Cryo EM<br /> | ||
**[[5t0m]], [[5t0k]] - hKHMT EHMT2 SET domain + SAM + SAH + H3 peptide<br /> | **[[5t0m]], [[5t0k]] - hKHMT EHMT2 SET domain + SAM + SAH + H3 peptide<br /> | ||
**[[5ls6]], [[5hyn]] - hKHMT Ezh2in+ polycomb complex + inhibitor<br /> | **[[5ls6]], [[5hyn]] - hKHMT Ezh2in+ polycomb complex + inhibitor<br /> | ||
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**[[6ugh]] – hPRMT5 + MEP50 – Cryo EM<br /> | **[[6ugh]] – hPRMT5 + MEP50 – Cryo EM<br /> | ||
**[[5egs]], [[5wcf]], [[5lv5]], [[5lv4]], [[5lv3]], [[5lv2]] – hPRMT6 + inhibitor<br /> | **[[5egs]], [[5wcf]], [[5lv5]], [[5lv4]], [[5lv3]], [[5lv2]] – hPRMT6 + inhibitor<br /> | ||
| + | **[[5dst]] – hPRMT8 catalytic domain + SAH<br /> | ||
**[[5ih3]] – mPRMT4 + SAH<br /> | **[[5ih3]] – mPRMT4 + SAH<br /> | ||
**[[5k8v]], [[5isi]], [[5ish]], [[5isg]], [[5isf]], [[5ise]], [[5isd]], [[5isc]], [[5isb]], [[5isa]], [[5is9]], [[5is8]], [[5is7]], [[5is6]], [[5tbj]], [[5tbi]], [[5tbh]], [[5ntc]], [[5lkj]], [[5k8x]], [[5k8w]] – mPRMT4 + inhibitor<br /> | **[[5k8v]], [[5isi]], [[5ish]], [[5isg]], [[5isf]], [[5ise]], [[5isd]], [[5isc]], [[5isb]], [[5isa]], [[5is9]], [[5is8]], [[5is7]], [[5is6]], [[5tbj]], [[5tbi]], [[5tbh]], [[5ntc]], [[5lkj]], [[5k8x]], [[5k8w]] – mPRMT4 + inhibitor<br /> | ||
**[[5lgs]], [[5lgr]], [[5lgq]], [[5lgp]] – mPRMT4 + poly(A)-binding protein peptide + inhibitor<br /> | **[[5lgs]], [[5lgr]], [[5lgq]], [[5lgp]] – mPRMT4 + poly(A)-binding protein peptide + inhibitor<br /> | ||
| - | **[[4c04]], [[6sq3]], [[6sq4]] – | + | **[[4c04]], [[6sq3]], [[6sq4]], [[7nud]], [[7nue]], [[7p2r]], [[7ppq]], [[7ppy]], [[7pu8]], [[7puc]], [[7puq]], [[7pv6]] – mPRMT 6 + inhibitor<br /> |
| + | **[[6sqk]] – mPRMT 6 + peptide<br /> | ||
| + | **[[7os4]] – mPRMT 6 + histone H3.1<br /> | ||
| + | **[[7okp]] – mPRMT 6 + histone H3.3<br /> | ||
**[[4c05]], [[5fqo]], [[5fqn]] – mPRMT6 + SAH<br /> | **[[4c05]], [[5fqo]], [[5fqn]] – mPRMT6 + SAH<br /> | ||
**[[4c4a]] – mPRMT7 + SAH<br /> | **[[4c4a]] – mPRMT7 + SAH<br /> | ||
Current revision
3D Structures of histone methyltransferase
Updated on 22-May-2023
