Integrin 3D structures
From Proteopedia
(Difference between revisions)
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**[[2k1a]] - hIG transmembrane domain – NMR<BR /> | **[[2k1a]] - hIG transmembrane domain – NMR<BR /> | ||
| - | *IG α-1 β-1 (CD49a-CD49b) | + | *IG α-1 + IG β-1 (CD49a-CD49b) |
**[[1qc5]], [[1qcy]] - hIG I domain (mutant) + Mg<br /> | **[[1qc5]], [[1qcy]] - hIG I domain (mutant) + Mg<br /> | ||
**[[1pt6]] - hIG I domain + Mg<br /> | **[[1pt6]] - hIG I domain + Mg<br /> | ||
| - | *IG α-2 (CD49b) β | + | *IG α-2 (CD49b) + IG β |
**[[5hj2]] - hIG I domain<br /> | **[[5hj2]] - hIG I domain<br /> | ||
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**[[2k1a]] - hIG transmembrane domain – NMR<br /> | **[[2k1a]] - hIG transmembrane domain – NMR<br /> | ||
| - | *IG α-2b β-3 (CD61) | + | *IG α-2b + IG β-3 (CD61) |
**[[1kup]], [[1kuz]] – hIG proximal domain – NMR<BR /> | **[[1kup]], [[1kuz]] – hIG proximal domain – NMR<BR /> | ||
**[[1m8o]] - hIG cytoplasmic domain – NMR<BR /> | **[[1m8o]] - hIG cytoplasmic domain – NMR<BR /> | ||
**[[4cak]] – hIG – Cryo-EM<br /> | **[[4cak]] – hIG – Cryo-EM<br /> | ||
| - | **[[2k9j]], [[2knc]] - hIG transmembrane domain – NMR<BR /> | + | **[[2k9j]], [[2knc]], [[7kn0]] - hIG transmembrane domain – NMR<BR /> |
**[[1tye]], [[3fcu]], [[3fcs]] – hIG + Mg<br /> | **[[1tye]], [[3fcu]], [[3fcs]] – hIG + Mg<br /> | ||
**[[3fc3]] – hIG (mutant) + Mg<br /> | **[[3fc3]] – hIG (mutant) + Mg<br /> | ||
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**[[2vdm]], [[2vdn]], [[3t3m]], [[3t3p]] – hIG headpiece + antibody + antagonist + Mg<br /> | **[[2vdm]], [[2vdn]], [[3t3m]], [[3t3p]] – hIG headpiece + antibody + antagonist + Mg<br /> | ||
**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hIG headpiece + antibody + fibrinogen peptide + Mg<br /> | **[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hIG headpiece + antibody + fibrinogen peptide + Mg<br /> | ||
| - | **[[6v4p]] – hIG + antibody – Cryo-EM<br /> | + | **[[6v4p]], [[7la4]] – hIG + antibody – Cryo-EM<br /> |
| + | **[[7l8p]], [[7tct]], [[7td8]], [[7tho]], [[7tmz]], [[7tpd]], [[7u60]], [[7u9f]], [[7u9v]], [[7ubr]], [[7ucy]], [[7udg]], [[7udh]], [[7ue0]], [[7ufh]], [[7uh8]], [[7uje]], [[7ujk]], [[7uk9]], [[7uko]], [[7ukp]], [[7ukt]] – hIG + antibody + drug<br /> | ||
*IG α-4 | *IG α-4 | ||
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**[[4irz]] - hIG + antibody <br /> | **[[4irz]] - hIG + antibody <br /> | ||
| - | *IG α-4 (CD49d) β-7 | + | *IG α-4 (CD49d) + IG β-7 |
**[[3v4p]] - hIG headpiece (mutant) + antibody + Mg<br /> | **[[3v4p]] - hIG headpiece (mutant) + antibody + Mg<br /> | ||
**[[3v4v]] - hIG headpiece (mutant) + antibody + inhibitor + Mg<br /> | **[[3v4v]] - hIG headpiece (mutant) + antibody + inhibitor + Mg<br /> | ||
| - | *IG α-5 (CD49e) β-1 (CD29) | + | *IG α-5 (CD49e) + IG β-1 (CD29) |
| + | **[[7nxd]] – hIG + Mg – Cryo-EM<br /> | ||
| + | **[[7nwl]] – hIG + fibronectin + laminin – Cryo-EM<br /> | ||
**[[4wjk]] - hIG headpiece (mutant) + Mg<br /> | **[[4wjk]] - hIG headpiece (mutant) + Mg<br /> | ||
**[[4wk0]], [[4wk2]], [[4wk4]] - hIG headpiece (mutant) + peptide + Mg<br /> | **[[4wk0]], [[4wk2]], [[4wk4]] - hIG headpiece (mutant) + peptide + Mg<br /> | ||
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**[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br /> | **[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br /> | ||
| - | *IG α-5 (CD49e) β-3 (CD61) ectodomain | + | *IG α-5 (CD49e) + IG β-3 (CD61) ectodomain |
**[[3ije]], [[1m1x]], [[4g1e]], [[4g1m]], [[1u8c]] – hIG + cation<br /> | **[[3ije]], [[1m1x]], [[4g1e]], [[4g1m]], [[1u8c]] – hIG + cation<br /> | ||
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**[[1l5g]] - hIG + tripeptide + Mn<br /> | **[[1l5g]] - hIG + tripeptide + Mn<br /> | ||
| - | *IG α-5 β-6 | + | *IG α-5 + IG β-6 |
**[[4um8]] – hIG headpiece (mutant) + Ni<br /> | **[[4um8]] – hIG headpiece (mutant) + Ni<br /> | ||
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**[[5neu]], [[5net]], [[5ner]], [[5nem]] – hIG headpiece + foot-and-mouth virus – Cryo EM<br /> | **[[5neu]], [[5net]], [[5ner]], [[5nem]] – hIG headpiece + foot-and-mouth virus – Cryo EM<br /> | ||
**[[5ffo]] – hIG headpiece + TGF-beta-1<br /> | **[[5ffo]] – hIG headpiece + TGF-beta-1<br /> | ||
| + | |||
| + | *IG α-6 + IG β-1 | ||
| + | **[[7ceb]], [[7cec]] – hIG headpiece + laminin + Mg<br /> | ||
*IG α-L | *IG α-L | ||
| - | **[[4ixd]] | + | **[[1lfa]] - hIG I domain + Mn <br /> |
| + | **[[1zon]], [[4ixd]], [[7kc3]] - hIG I domain 153-334 <br /> | ||
| + | **[[1mqa]] - hIG I domain (mutant) <br /> | ||
| + | **[[1zoo]], [[1zop]], [[3f74]] - hIG I domain + Mg <br /> | ||
| + | **[[1mq9]] - hIG I domain (mutant) + Mn <br /> | ||
| + | **[[1mjn]] - hIG I domain (mutant) + Mg <br /> | ||
| + | **[[2k8o]] – hIG cytoplasmic domain (mutant) – NMR <br /> | ||
**[[5e6s]], [[5e6r]] – hIG AI, headpiece,pocket domains + Mg<br /> | **[[5e6s]], [[5e6r]] – hIG AI, headpiece,pocket domains + Mg<br /> | ||
**[[2m3e]] – hIG transmembrane domain - NMR<br /> | **[[2m3e]] – hIG transmembrane domain - NMR<br /> | ||
| - | *IG α-L β-2 | + | *IG α-L complexes |
| + | |||
| + | **[[1cqp]] - hIG I domain + lovastatin + Mg <br /> | ||
| + | **[[1mq8]], [[3bn3]], [[3tcx]] - hIG I domain (mutant) + intracellular adhesion molecule + Mg <br /> | ||
| + | **[[1t0p]] - hIG I domain + intracellular adhesion molecule-3 + Mg<br /> | ||
| + | **[[1rd4]], [[2ica]], [[3bqm]], [[3bqn]], [[3e2m]] - hIG I domain + inhibitor<br /> | ||
| + | **[[2o7n]], [[3m6f]] - hIG I domain + antagonist<br /> | ||
| + | **[[1xdd]], [[1xdg]], [[1xuo]], [[7kc5]] - hIG I domain + inhibitor + Mg<br /> | ||
| + | **[[7kc6]] - hIG I domain + drug + Mg<br /> | ||
| + | **[[3f78]] - hIG I domain + anesthetic + Mg<br /> | ||
| + | **[[3eoa]], [[3eob]] - hIG I domain + antibody<br /> | ||
| + | **[[3hi6]] - hIG I domain (mutant) + antibody + Mn<br /> | ||
| + | |||
| + | *IG α-L + IG β-2 | ||
**[[5e6u]] – hIG headpiece (mutant) + Ni<br /> | **[[5e6u]] – hIG headpiece (mutant) + Ni<br /> | ||
| - | *IG α-V β-3 | + | *IG α-M |
| + | |||
| + | **[[1idn]], [[1na5]] - hIG<br /> | ||
| + | **[[1mf7]] - hIG (mutant) <br /> | ||
| + | **[[1bho]] - hIG + Mg<br /> | ||
| + | **[[1bhq]] - hIG + Cd<br /> | ||
| + | **[[1m1u]] - hIG (mutant) + Ca<br /> | ||
| + | **[[1n9z]] - hIG (mutant) + Mg<br /> | ||
| + | **[[3q3g]], [[3qa3]] – hIG + antibody<br /> | ||
| + | **[[4m76]] – hIG + complement C3<br /> | ||
| + | **[[2lke]], [[2lkj]] – hIG cytoplasmic domain – NMR<br /> | ||
| + | **[[4xw2]] – hIG + simvastatin<br /> | ||
| + | **[[6rhv]], [[6rhw]] – hIG + cytolysin<br /> | ||
| + | |||
| + | *IG α-M + IG β-2 | ||
| + | |||
| + | **[[7usm]] – hIG ectodomain – Cryo EM<br /> | ||
| + | **[[7usl]] – hIG ectodomain + adenylate cyclase toxin + antibody – Cryo EM<br /> | ||
| + | **[[7p2d]] – hIG ectodomain + nanobody <br /> | ||
| + | |||
| + | *IG α-V + IG β-3 | ||
**[[6mk0]] – hIG + antagonist<br /> | **[[6mk0]] – hIG + antagonist<br /> | ||
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**[[6naj]] – hIG + fibronectin<br /> | **[[6naj]] – hIG + fibronectin<br /> | ||
| - | *IG α-V β-8 | + | *IG α-V + IG β-8 |
**[[6djp]], [[6ujb]], [[6ujc]] – hIG + antibody – Cryo EM<br /> | **[[6djp]], [[6ujb]], [[6ujc]] – hIG + antibody – Cryo EM<br /> | ||
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**[[6om2]] – hIG (mutant) + Protgf-b1 RGD peptide<br /> | **[[6om2]] – hIG (mutant) + Protgf-b1 RGD peptide<br /> | ||
**[[6uja]] – hIG + Protgf-b1 RGD – Cryo EM<br /> | **[[6uja]] – hIG + Protgf-b1 RGD – Cryo EM<br /> | ||
| + | **[[7y1t]] – hIG + TGF-b1 – Cryo EM<br /> | ||
*IG α-X | *IG α-X | ||
**[[2luv]] – hIG cytoplasmic domain – NMR<BR /> | **[[2luv]] – hIG cytoplasmic domain – NMR<BR /> | ||
| + | **[[1n3y]] – hIG domain I (mutant)<br /> | ||
| - | *IG α-X β-2 (CD18) | + | *IG α-X + IG β-2 (CD18) |
**[[3k6s]], [[3k71]], [[3k72]], [[5es4]] – hIG + Mg<br /> | **[[3k6s]], [[3k71]], [[3k72]], [[5es4]] – hIG + Mg<br /> | ||
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**[[2l1c]] – hIG cytoplasmic tail + SHC<br /> | **[[2l1c]] – hIG cytoplasmic tail + SHC<br /> | ||
**[[2mtp]] – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain<br /> | **[[2mtp]] – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain<br /> | ||
| + | **[[6bxb]], [[6bxf]] – hIG/hIG α-L <br /> | ||
*IG β-4 (CD104; Gp150) | *IG β-4 (CD104; Gp150) | ||
Current revision
3D structures of integrin
Updated on 31-May-2023
