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7vib
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7vib is ON HOLD until Paper Publication Authors: Guo, Y., Cao, W., Jia, N., Wang, W., Yuan, S., Wang, Y. Description: Crystal structure of human AC...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human ACE2 and GX/P2V RBD== | |
| - | + | <StructureSection load='7vib' size='340' side='right'caption='[[7vib]], [[Resolution|resolution]] 3.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7vib]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pangolin_coronavirus Pangolin coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7VIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7VIB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7vib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7vib OCA], [https://pdbe.org/7vib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7vib RCSB], [https://www.ebi.ac.uk/pdbsum/7vib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7vib ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/ACE2_HUMAN ACE2_HUMAN] Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.<ref>PMID:10969042</ref> <ref>PMID:10924499</ref> <ref>PMID:14647384</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: Yuan | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pangolin coronavirus]] | ||
| + | [[Category: Cao W]] | ||
| + | [[Category: Guo Y]] | ||
| + | [[Category: Jia N]] | ||
| + | [[Category: Wang W]] | ||
| + | [[Category: Wang Y]] | ||
| + | [[Category: Yuan S]] | ||
Current revision
Crystal structure of human ACE2 and GX/P2V RBD
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Categories: Homo sapiens | Large Structures | Pangolin coronavirus | Cao W | Guo Y | Jia N | Wang W | Wang Y | Yuan S
