1fc6

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[[Image:1fc6.gif|left|200px]]
 
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==PHOTOSYSTEM II D1 C-TERMINAL PROCESSING PROTEASE==
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The line below this paragraph, containing "STRUCTURE_1fc6", creates the "Structure Box" on the page.
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<StructureSection load='1fc6' size='340' side='right'caption='[[1fc6]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fc6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetradesmus_obliquus Tetradesmus obliquus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FC6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1fc6| PDB=1fc6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fc6 OCA], [https://pdbe.org/1fc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fc6 RCSB], [https://www.ebi.ac.uk/pdbsum/1fc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fc6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CTPA_TETOB CTPA_TETOB] Protease involved in the C-terminal processing of the chloroplastic D1 protein of photosystem II. This proteolytic processing is necessary to allow the light-driven assembly of the tetranuclear manganese cluster, which is responsible for photosynthetic water oxidation.<ref>PMID:9252339</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fc/1fc6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fc6 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We report here the first three-dimensional structure of the D1 C-terminal processing protease (D1P), which is encoded by the ctpA gene. This enzyme removes the C-terminal extension of the D1 polypeptide of photosystem II of oxygenic photosynthesis. Proteolytic processing is necessary to allow the light driven assembly of the tetranuclear manganese cluster, which is responsible for photosynthetic water oxidation. The X-ray structure of the Scenedesmus obliquus enzyme has been determined at 1.8 A resolution using the multiwavelength anomalous dispersion method. The enzyme is monomeric and is composed of three folding domains. The middle domain is topologically homologous to known PDZ motifs and is proposed to be the site at which the substrate C-terminus binds. The remainder of the substrate likely extends across the face of the enzyme, interacting at its scissile bond with the enzyme active site Ser 372 / Lys 397 catalytic dyad, which lies at the center of the protein at the interface of the three domains.
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'''PHOTOSYSTEM II D1 C-TERMINAL PROCESSING PROTEASE'''
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Crystal structures of the photosystem II D1 C-terminal processing protease.,Liao DI, Qian J, Chisholm DA, Jordan DB, Diner BA Nat Struct Biol. 2000 Sep;7(9):749-53. PMID:10966643<ref>PMID:10966643</ref>
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==Overview==
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We report here the first three-dimensional structure of the D1 C-terminal processing protease (D1P), which is encoded by the ctpA gene. This enzyme removes the C-terminal extension of the D1 polypeptide of photosystem II of oxygenic photosynthesis. Proteolytic processing is necessary to allow the light driven assembly of the tetranuclear manganese cluster, which is responsible for photosynthetic water oxidation. The X-ray structure of the Scenedesmus obliquus enzyme has been determined at 1.8 A resolution using the multiwavelength anomalous dispersion method. The enzyme is monomeric and is composed of three folding domains. The middle domain is topologically homologous to known PDZ motifs and is proposed to be the site at which the substrate C-terminus binds. The remainder of the substrate likely extends across the face of the enzyme, interacting at its scissile bond with the enzyme active site Ser 372 / Lys 397 catalytic dyad, which lies at the center of the protein at the interface of the three domains.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1FC6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Scenedesmus_obliquus Scenedesmus obliquus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FC6 OCA].
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</div>
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<div class="pdbe-citations 1fc6" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Crystal structures of the photosystem II D1 C-terminal processing protease., Liao DI, Qian J, Chisholm DA, Jordan DB, Diner BA, Nat Struct Biol. 2000 Sep;7(9):749-53. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10966643 10966643]
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*[[Photosystem II 3D structures|Photosystem II 3D structures]]
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[[Category: Scenedesmus obliquus]]
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== References ==
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[[Category: Single protein]]
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<references/>
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[[Category: Chisholm, D A.]]
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__TOC__
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[[Category: Diner, B A.]]
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</StructureSection>
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[[Category: Jordan, D B.]]
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[[Category: Large Structures]]
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[[Category: Liao, D I.]]
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[[Category: Tetradesmus obliquus]]
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[[Category: Qian, J.]]
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[[Category: Chisholm DA]]
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[[Category: D1 c-terminal processing protease]]
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[[Category: Diner BA]]
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[[Category: Pdz domain]]
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[[Category: Jordan DB]]
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[[Category: Photosynthesis]]
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[[Category: Liao DI]]
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[[Category: Photosystem ii]]
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[[Category: Qian J]]
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[[Category: Serine protease]]
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[[Category: Serine-lysine catalytic dyad]]
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[[Category: X-ray crystal structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:09:32 2008''
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Current revision

PHOTOSYSTEM II D1 C-TERMINAL PROCESSING PROTEASE

PDB ID 1fc6

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