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1wct

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Current revision (07:51, 12 July 2023) (edit) (undo)
 
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==A NOVEL CONOTOXIN FROM CONUS TEXTILE WITH UNUSUAL POST-TRANSLATIONAL MODIFICATIONS REDUCES PRESYNAPTIC CALCIUM INFLUX, NMR, 1 STRUCTURE, GLYCOSYLATED PROTEIN==
==A NOVEL CONOTOXIN FROM CONUS TEXTILE WITH UNUSUAL POST-TRANSLATIONAL MODIFICATIONS REDUCES PRESYNAPTIC CALCIUM INFLUX, NMR, 1 STRUCTURE, GLYCOSYLATED PROTEIN==
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<StructureSection load='1wct' size='340' side='right'caption='[[1wct]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
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<StructureSection load='1wct' size='340' side='right'caption='[[1wct]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1wct]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_textile Conus textile]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WCT FirstGlance]. <br>
<table><tr><td colspan='2'>[[1wct]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_textile Conus textile]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WCT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTR:6-BROMO-TRYPTOPHAN'>BTR</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTR:6-BROMO-TRYPTOPHAN'>BTR</scene>, <scene name='pdbligand=CGU:GAMMA-CARBOXY-GLUTAMIC+ACID'>CGU</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wct OCA], [https://pdbe.org/1wct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wct RCSB], [https://www.ebi.ac.uk/pdbsum/1wct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wct ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wct OCA], [https://pdbe.org/1wct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wct RCSB], [https://www.ebi.ac.uk/pdbsum/1wct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wct ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CT5A_CONTE CT5A_CONTE]] Epsilon-conotoxins act at presynaptic membranes, blocking the calcium channels or G protein-coupled receptors. Causes hyperactivity upon intracranial injection into mice. Causes dorsal fins drooping in fish.<ref>PMID:10318957</ref>
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[https://www.uniprot.org/uniprot/CT5AS_CONTE CT5AS_CONTE] Epsilon-conotoxins act at presynaptic membranes, blocking the calcium channels or G protein-coupled receptors. Causes hyperactivity upon intracranial injection into mice. Causes dorsal fins drooping in fish.<ref>PMID:10318957</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Conus textile]]
[[Category: Conus textile]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Baleja, J D]]
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[[Category: Baleja JD]]
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[[Category: Czerwiec, E]]
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[[Category: Czerwiec E]]
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[[Category: Furie, B]]
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[[Category: Furie B]]
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[[Category: Furie, B C]]
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[[Category: Furie BC]]
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[[Category: Hambe, B]]
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[[Category: Hambe B]]
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[[Category: Rigby, A C]]
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[[Category: Rigby AC]]
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[[Category: Stenflo, J]]
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[[Category: Stenflo J]]
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[[Category: Calcium channel blocker]]
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[[Category: Gamma-carboxy glutamic acid]]
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[[Category: Novel omega conotoxin]]
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Current revision

A NOVEL CONOTOXIN FROM CONUS TEXTILE WITH UNUSUAL POST-TRANSLATIONAL MODIFICATIONS REDUCES PRESYNAPTIC CALCIUM INFLUX, NMR, 1 STRUCTURE, GLYCOSYLATED PROTEIN

PDB ID 1wct

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