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3gxx

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Current revision (07:13, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3gxx' size='340' side='right'caption='[[3gxx]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3gxx' size='340' side='right'caption='[[3gxx]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3gxx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_2001 Atcc 2001]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GXX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3gxx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata Candida glabrata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GXX FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3gxw|3gxw]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CAGL0L04774g, SPT6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5478 ATCC 2001])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gxx OCA], [https://pdbe.org/3gxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gxx RCSB], [https://www.ebi.ac.uk/pdbsum/3gxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gxx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gxx OCA], [https://pdbe.org/3gxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gxx RCSB], [https://www.ebi.ac.uk/pdbsum/3gxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gxx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SPT6_CANGA SPT6_CANGA]] Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).
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[https://www.uniprot.org/uniprot/SPT6_CANGA SPT6_CANGA] Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 2001]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cramer, P]]
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[[Category: Cramer P]]
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[[Category: Dengl, S]]
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[[Category: Dengl S]]
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[[Category: Mayer, A]]
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[[Category: Mayer A]]
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[[Category: Sun, M]]
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[[Category: Sun M]]
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[[Category: C-terminal alpha helix]]
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[[Category: N-terminal alpha helix]]
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[[Category: Nucleus]]
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[[Category: Sh2 domain]]
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[[Category: Sh2-fold]]
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[[Category: Three stranded anti-parallel beta sheet]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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Current revision

Structure of the SH2 domain of the Candida glabrata transcription elongation factor Spt6, crystal form B

PDB ID 3gxx

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