3jxt
From Proteopedia
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<StructureSection load='3jxt' size='340' side='right'caption='[[3jxt]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='3jxt' size='340' side='right'caption='[[3jxt]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3jxt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3jxt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JXT FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4DB:(2S)-2-AMINO-4-[5-(DIMETHYLAMINO)-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL]BUTANOIC+ACID'>4DB</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jxt OCA], [https://pdbe.org/3jxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jxt RCSB], [https://www.ebi.ac.uk/pdbsum/3jxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jxt ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jxt OCA], [https://pdbe.org/3jxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jxt RCSB], [https://www.ebi.ac.uk/pdbsum/3jxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jxt ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [[https://www.uniprot.org/uniprot/CCG2_MOUSE CCG2_MOUSE]] Note=Defects in Cacng2 cause the stargazer (stg) phenotype. Stg mice have spike-wave seizures characteristic of absence epilepsy, with accompanying defects in the cerebellum and inner ear. | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/DLG3_RAT DLG3_RAT] Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling (By similarity). | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/3jxt_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/3jxt_consurf.spt"</scriptWhenChecked> | ||
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Buffalo rat]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: | + | [[Category: Rattus norvegicus]] |
| - | [[Category: | + | [[Category: Imperiali B]] |
| - | [[Category: | + | [[Category: Olivier NB]] |
| - | [[Category: | + | [[Category: Sainlos M]] |
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Current revision
Crystal structure of the third PDZ domain of SAP-102 in complex with a fluorogenic peptide-based ligand
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