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3lz9

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Current revision (08:46, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3lz9' size='340' side='right'caption='[[3lz9]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
<StructureSection load='3lz9' size='340' side='right'caption='[[3lz9]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3lz9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/American_tobacco American tobacco]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LZ9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3lz9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LZ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LZ9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPF:(2Z,6E)-2-FLUORO-3,7,11-TRIMETHYLDODECA-2,6,10-TRIEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>FPF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EAS3, EAS4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4097 American tobacco])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPF:(2Z,6E)-2-FLUORO-3,7,11-TRIMETHYLDODECA-2,6,10-TRIEN-1-YL+TRIHYDROGEN+DIPHOSPHATE'>FPF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aristolochene_synthase Aristolochene synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.9 4.2.3.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lz9 OCA], [https://pdbe.org/3lz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lz9 RCSB], [https://www.ebi.ac.uk/pdbsum/3lz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lz9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lz9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lz9 OCA], [https://pdbe.org/3lz9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lz9 RCSB], [https://www.ebi.ac.uk/pdbsum/3lz9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lz9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/5EAS_TOBAC 5EAS_TOBAC]] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene.
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[https://www.uniprot.org/uniprot/5EAS_TOBAC 5EAS_TOBAC] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: American tobacco]]
 
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[[Category: Aristolochene synthase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Coates, R M]]
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[[Category: Nicotiana tabacum]]
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[[Category: Dellas, N]]
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[[Category: Coates RM]]
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[[Category: Faraldos, J A]]
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[[Category: Dellas N]]
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[[Category: Hess, B A]]
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[[Category: Faraldos JA]]
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[[Category: Maille, P E.O]]
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[[Category: Hess Jr BA]]
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[[Category: Noel, J P]]
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[[Category: Noel JP]]
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[[Category: Smentek, L]]
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[[Category: O'Maille PE]]
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[[Category: Zhao, M]]
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[[Category: Smentek L]]
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[[Category: 5-epi-aristolochene synthase]]
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[[Category: Zhao M]]
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[[Category: Cytoplasm]]
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[[Category: Lyase]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: Metal-binding domain]]
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[[Category: Plant terpenoid cyclase]]
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Current revision

The Crystal Structure of 5-epi-aristolochene synthase M4 mutant complexed with (2-trans,6-trans)-2-fluorofarnesyl diphosphate

PDB ID 3lz9

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