This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


7nuw

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:40, 1 February 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='7nuw' size='340' side='right'caption='[[7nuw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='7nuw' size='340' side='right'caption='[[7nuw]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[7nuw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NUW FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[7nuw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NUW FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TLR1, KIAA0012 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/ADP-ribosyl_cyclase/cyclic_ADP-ribose_hydrolase ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.6 3.2.2.6] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nuw OCA], [https://pdbe.org/7nuw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nuw RCSB], [https://www.ebi.ac.uk/pdbsum/7nuw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nuw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nuw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nuw OCA], [https://pdbe.org/7nuw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nuw RCSB], [https://www.ebi.ac.uk/pdbsum/7nuw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nuw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/TLR1_HUMAN TLR1_HUMAN]] Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
+
[https://www.uniprot.org/uniprot/TLR1_HUMAN TLR1_HUMAN] Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 23: Line 22:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase]]
+
[[Category: Homo sapiens]]
-
[[Category: Human]]
+
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Borshchevskiy, V I]]
+
[[Category: Borshchevskiy VI]]
-
[[Category: Luginina, A P]]
+
[[Category: Luginina AP]]
-
[[Category: Lushpa, V A]]
+
[[Category: Lushpa VA]]
-
[[Category: Mineev, K S]]
+
[[Category: Mineev KS]]
-
[[Category: Shevtsov, M B]]
+
[[Category: Shevtsov MB]]
-
[[Category: Vakhrameev, D D]]
+
[[Category: Vakhrameev DD]]
-
[[Category: Signaling protein]]
+
-
[[Category: Tir domain]]
+
-
[[Category: Toll-like receptor]]
+

Current revision

Crystal structure of the TIR domain of human TLR1 (crystallised with Zn2+ ions)

PDB ID 7nuw

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7nuw"
Personal tools