1aqb

From Proteopedia

(Difference between revisions)

Current revision

RETINOL-BINDING PROTEIN (RBP) FROM PIG PLASMA

Structural highlights

1aqb is a 1 chain structure with sequence from Sus scrofa domesticus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.65Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RET4_PIG Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The crystal structure of pig plasma retinol-binding protein (RBP) has been determined at 1.65 A resolution. The space group is P212121, with a = 45.81 (4), b = 53.14 (5), c = 72.97 (8) A and one protein molecule in the asymmetric unit. The structure has been solved using the molecular replacement method and refined with restrained least squares to an R factor of 0.1844 and an Rfree of 0.237 for 18 874 and 1001 independent reflections, respectively. The relatively high resolution structure of pig holoRBP has revealed some new structural details. Moreover, it has provided a description of the binding site for Cd2+, a metal ion which is required for protein crystallization. The hepta-coordination of the RBP-bound cadmium ion involves different residues of two symmetry-related RBP molecules, consistent with the participation of the cation in intermolecular interactions that in turn promote protein crystallization.

Structure of pig plasma retinol-binding protein at 1.65 A resolution.,Zanotti G, Panzalorto M, Marcato A, Malpeli G, Folli C, Berni R Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):1049-52. PMID:9757135^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Zanotti G, Panzalorto M, Marcato A, Malpeli G, Folli C, Berni R. Structure of pig plasma retinol-binding protein at 1.65 A resolution. Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):1049-52. PMID:9757135

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1aqb"

@@ Line 3: / Line 3: @@
 <StructureSection load='1aqb' size='340' side='right'caption='[[1aqb]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1aqb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa_domestica Sus scrofa domestica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AQB FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1aqb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa_domesticus Sus scrofa domesticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AQB FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=RTL:RETINOL'>RTL</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=RTL:RETINOL'>RTL</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1aqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aqb OCA], [https://pdbe.org/1aqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1aqb RCSB], [https://www.ebi.ac.uk/pdbsum/1aqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1aqb ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/RET4_PIG RET4_PIG]] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
+[https://www.uniprot.org/uniprot/RET4_PIG RET4_PIG] Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 14: / Line 15: @@
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/aq/1aqb_consurf.spt"</scriptWhenChecked>
-    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
@@ Line 36: / Line 37: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Sus scrofa domestica]]
+[[Category: Sus scrofa domesticus]]
-[[Category: Berni, R]]
+[[Category: Berni R]]
-[[Category: Folli, C]]
+[[Category: Folli C]]
-[[Category: Malpeli, G]]
+[[Category: Malpeli G]]
-[[Category: Marcato, A]]
+[[Category: Marcato A]]
-[[Category: Panzalorto, M]]
+[[Category: Panzalorto M]]
-[[Category: Zanotti, G]]
+[[Category: Zanotti G]]
-[[Category: Cadmium ion]]
-[[Category: Retinoid]]
-[[Category: Retinol transport]]
-[[Category: Vitamin some]]

1aqb

From Proteopedia

Current revision

RETINOL-BINDING PROTEIN (RBP) FROM PIG PLASMA

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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