Isocitrate dehydrogenase 3D structures

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Line 7: Line 7:
**[[6kdf]] – hIDH3 α,β subunits - human<br />
**[[6kdf]] – hIDH3 α,β subunits - human<br />
-
**[[6kde]] – hIDH3 α,β subunits + Ca <br />
+
**[[8grb]], [[8gs5]] – hIDH3 a (mutant),b subunits <br />
 +
**[[6kde]] – hIDH3 a,b subunits + Ca <br />
 +
**[[8grg]] – hIDH3 a,g subunits <br />
**[[5grh]] – hIDH3 α,γ subunits + Mg <br />
**[[5grh]] – hIDH3 α,γ subunits + Mg <br />
**[[7ce3]] – hIDH3 α,β,γ subunits<br />
**[[7ce3]] – hIDH3 α,β,γ subunits<br />
Line 13: Line 15:
**[[2uxq]] – DpIDH – ''Desulfotalea psychrophila''<br />
**[[2uxq]] – DpIDH – ''Desulfotalea psychrophila''<br />
**[[3dms]] – IDH – ''Burkholderia pseudomallei''<br />
**[[3dms]] – IDH – ''Burkholderia pseudomallei''<br />
-
**[[2e0c]], [[2dht]] - StIDH – ''Sulfolobus tokodaii''<br />
+
**[[2dht]], [[2e0c]] - StIDH – ''Sulfolobus tokodaii''<br />
**[[2iv0]] – IDH – ''Archaeoglobus fulgidus''<br />
**[[2iv0]] – IDH – ''Archaeoglobus fulgidus''<br />
**[[1zor]] – IDH – ''Thermotoga maritima''<br />
**[[1zor]] – IDH – ''Thermotoga maritima''<br />
**[[2b0t]] – IDH – ''Corynebacterium glutamicum''<br />
**[[2b0t]] – IDH – ''Corynebacterium glutamicum''<br />
-
**[[1xgv]], [[1v94]] - ApIDH – ''Aeropyrum pernix''<br />
+
**[[1v94]], [[1xgv]] - ApIDH – ''Aeropyrum pernix''<br />
-
**[[1pb3]], [[1sjs]], [[6icd]], [[7icd]], [[3icd]] – EcIDH – ''Escherichia coli''<br />
+
**[[1pb3]], [[1sjs]], [[3icd]], [[6icd]], [[7icd]] – EcIDH – ''Escherichia coli''<br />
**[[1idd]], [[1idf]], [[4icd]] - EcIDH (mutant)<br />
**[[1idd]], [[1idf]], [[4icd]] - EcIDH (mutant)<br />
**[[3ah3]] – TtIDH – ''Thermus thermophilus''<br />
**[[3ah3]] – TtIDH – ''Thermus thermophilus''<br />
Line 28: Line 30:
**[[6lkz]] – IDH – ''Phaeodactylum tricomutum''<br />
**[[6lkz]] – IDH – ''Phaeodactylum tricomutum''<br />
**[[6ltf]], [[6m3s]] – IDH – ''Xanthomonas campestris''<br />
**[[6ltf]], [[6m3s]] – IDH – ''Xanthomonas campestris''<br />
 +
**[[7y1u]] – IDH – ''Campylobacter corcagiensis''<br />
*IDH+citrate
*IDH+citrate
Line 33: Line 36:
**[[5yfn]] – hIDH1 + isocitrate+ Mg<br />
**[[5yfn]] – hIDH1 + isocitrate+ Mg<br />
**[[5gri]] – hIDH3 α,γ subunits + citrate+ Mg<br />
**[[5gri]] – hIDH3 α,γ subunits + citrate+ Mg<br />
 +
**[[8grh]] – hIDH3 a (mutant),g subunits + citrate<br />
 +
**[[1lwd]] – IDH+isocitrate+Mn - pig<br />
**[[5h3f]] – mIDH 2 + isocitrate<br />
**[[5h3f]] – mIDH 2 + isocitrate<br />
**[[5h3e]] – mIDH 2 (mutant) + isocitrate<br />
**[[5h3e]] – mIDH 2 (mutant) + isocitrate<br />
Line 39: Line 44:
**[[2uxr]] – DpIDH+isocitric acid<br />
**[[2uxr]] – DpIDH+isocitric acid<br />
**[[1itw]] – AvIDH+isocitrate+Mn – ''Azotobacter vinelandii''<br />
**[[1itw]] – AvIDH+isocitrate+Mn – ''Azotobacter vinelandii''<br />
-
**[[1lwd]] – IDH+isocitrate+Mn - pig<br />
+
**[[1p8f]], [[1pb1]] – EcIDH+isocitrate <br />
-
**[[1pb1]], [[1p8f]] – EcIDH+isocitrate <br />
+
**[[1cw7]], [[5icd]], [[8icd]] - EcIDH +isocitrate+Mg<br />
**[[1cw7]], [[5icd]], [[8icd]] - EcIDH +isocitrate+Mg<br />
**[[1cw1]] - EcIDH (mutant)+isocitrate+Mn<br />
**[[1cw1]] - EcIDH (mutant)+isocitrate+Mn<br />
Line 51: Line 55:
**[[1t09]], [[5yfm]] – hIDH+NADP <br />
**[[1t09]], [[5yfm]] – hIDH+NADP <br />
-
**[[3mar]] – hIDH (mutant) + NADP<br />
+
**[[3mar]], [[8vh9]], [[8vhc]] – hIDH1 (mutant) + NADP<br />
**[[5k10]], [[5k11]] – hIDH + NADP – Cryo EM<br />
**[[5k10]], [[5k11]] – hIDH + NADP – Cryo EM<br />
**[[5svn]], [[5svo]] – hIDH2 (mutant) + NADP<br />
**[[5svn]], [[5svo]] – hIDH2 (mutant) + NADP<br />
Line 70: Line 74:
*IDH+α-ketoglutarate
*IDH+α-ketoglutarate
-
**[[3inm]], [[4l03]], [[4l04]], [[4l06]], [[5i95]] – hIDH1 (mutant)+NADPH+α-ketoglutarate+Ca <br />
+
**[[3inm]], [[4l03]], [[4l04]], [[4l06]], [[5i95]], [[8vha]], [[8vhb]] – hIDH1 (mutant)+NADPH+α-ketoglutarate+Ca <br />
**[[4kzo]] - hIDH1 +NADPH+α-ketoglutarate+Ca<br />
**[[4kzo]] - hIDH1 +NADPH+α-ketoglutarate+Ca<br />
**[[2qfy]] - yIDH+α-ketoglutarate<br />
**[[2qfy]] - yIDH+α-ketoglutarate<br />
Line 85: Line 89:
*IDH binary complex with inhibitor
*IDH binary complex with inhibitor
-
**[[6q6f]] – hIDH1 (mutant) + inhibitor<br />
+
**[8t7d]], [[9b81]] – hIDH + inhibitor<br />
-
**[[3asj]] – TtIDH + inhbibitor<br />
+
**[[6q6f]], [[8t7n]], [[8vhe]] – hIDH1 (mutant) + inhibitor<br />
 +
**[[3asj]] – TtIDH + inhibitor<br />
*IDH higher complexes
*IDH higher complexes
**[[3map]], [[6pay]] - hIDH1 +NADP+isocitrate<br />
**[[3map]], [[6pay]] - hIDH1 +NADP+isocitrate<br />
-
**[[3mas]] – hIDH1 (mutant) +NADP+isocitrate<br />
+
**[[3mas]], [[8vhd]] – hIDH1 (mutant) +NADP+isocitrate<br />
**[[1t0l]] – hIDH+NADP+isocitrate+Ca<br />
**[[1t0l]] – hIDH+NADP+isocitrate+Ca<br />
**[[5gre]], [[5grf]] – hIDH3 α,γ subunits + ADP+ citrate+ Mg<br />
**[[5gre]], [[5grf]] – hIDH3 α,γ subunits + ADP+ citrate+ Mg<br />
**[[5grl]] – hIDH3 α,γ subunits + ADP+ isocitrate+ Mg<br />
**[[5grl]] – hIDH3 α,γ subunits + ADP+ isocitrate+ Mg<br />
**[[5l57]], [[5l58]] - hIDH1 +NADP + inhibitor<br />
**[[5l57]], [[5l58]] - hIDH1 +NADP + inhibitor<br />
-
**[[4i3k]], [[4i3l]], [[4ja8]],[[4umx]], [[4umy]], [[4xrx]], [[4xs3]], [[5de1]], [[5lge]], [[5sun]], [[5svf]], [[6b0z]], [[5tqh]], [[6o2y]], [[6o2z]], [[6adg]], [[6u4j]], [[6vei]], [[6vg0]] - hIDH1 (mutant) +NADP + inhibitor<br />
+
**[[4i3k]], [[4i3l]], [[4ja8]],[[4umx]], [[4umy]], [[4xrx]], [[4xs3]], [[5de1]], [[5lge]], [[5sun]], [[5svf]], [[5tqh]], [[6adg]], [[6b0z]], [[6o2y]], [[6o2z]], [[6u4j]], [[6vei]], [[6vg0]] - hIDH1 (mutant) +NADP + inhibitor<br />
 +
**[[8t7o]] - hIDH1 (mutant) +NADP + drug<br />
**[[6bkx]], [[6bky]], [[6bkz]], [[6bl0]], [[6bl1]], [[6bl2]] – hIDH1 + isocitrate + inhibitor<br />
**[[6bkx]], [[6bky]], [[6bkz]], [[6bl0]], [[6bl1]], [[6bl2]] – hIDH1 + isocitrate + inhibitor<br />
**[[6adi]], [[6vfz]] – hIDH2 (mutant) +NADP + inhibitor<br />
**[[6adi]], [[6vfz]] – hIDH2 (mutant) +NADP + inhibitor<br />
**[[6l57]], [[6l59]] – hIDH3 a+g + citrate + ATP<br />
**[[6l57]], [[6l59]] – hIDH3 a+g + citrate + ATP<br />
-
**[[6bkx]], [[6bky]], [[6bkz]], [[6bl0]], [[6bl1]], [[6bl2]] - hIDH1 + isocitrate + inhibitor<br />
+
**[[8bay]] – hIDH1 (mutant) + NADP + butyloxoglutarate <br />
 +
**[[7pjn]], [[8hb9]] – hIDH1 (mutant) +NADP + inhibitor<br />
 +
**[[8grd]] – hIDH3 a+b + ADP + Mg<br />
**[[5svf]] - hIDH (mutant) +NADP + citrate + inhibitor<br />
**[[5svf]] - hIDH (mutant) +NADP + citrate + inhibitor<br />
-
**[[5i96]] – hIDH2 + NADP+ enasidenib + Ca<br />
+
**[[5i96]] – hIDH2 + NADP+ drug + Ca<br />
**[[5yzi]] - mIDH+NADP+citrate<br />
**[[5yzi]] - mIDH+NADP+citrate<br />
 +
**[[8w49]] - mIDH+NADP+ isocitrate<br />
 +
**[[8kib]] - mIDH+NADP+ oxaloacetate<br />
**[[3blw]] – yIDH+citrate+AMP<br />
**[[3blw]] – yIDH+citrate+AMP<br />
**[[2d4v]] – IDH+NAD+citrate – ''Acidithiobacillus thiooxidans''<br />
**[[2d4v]] – IDH+NAD+citrate – ''Acidithiobacillus thiooxidans''<br />
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**[[5svf]], [[6io0]] – hIDH1 (mutant) +NADP + citrate + inhibitor<br />
**[[5svf]], [[6io0]] – hIDH1 (mutant) +NADP + citrate + inhibitor<br />
 +
**[[8gru]] – hIDH1 (mutant) +NAD + isocitrate + Ca<br />
 +
**[[7pjm]] – hIDH1 (mutant) +NADP + oxoglutarate + Ca<br />
**[[1hj6]] – EcIDH (mutant)+NADP+isopropylmalate+Mg<br />
**[[1hj6]] – EcIDH (mutant)+NADP+isopropylmalate+Mg<br />
**[[1ai3]] - EcIDH +isocitrate+Mg+NDP<br />
**[[1ai3]] - EcIDH +isocitrate+Mg+NDP<br />
Line 123: Line 135:
**[[3lcb]] - EcIDH + IDH kinase/phosphatase + AMP + ATP<br />
**[[3lcb]] - EcIDH + IDH kinase/phosphatase + AMP + ATP<br />
**[[4aou]] - CtIDH + isocitrate+NADP+Mg<br />
**[[4aou]] - CtIDH + isocitrate+NADP+Mg<br />
-
**[[4aov]] - DpIDH + isocitrate+NADP+Mg
+
**[[4aov]] - DpIDH + isocitrate+NADP+Mg<br />
 +
**[[7e3n]] - TbIDH (mutant) +NADP + α-ketoglutarate + Ca<br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D Structures of Isocitrate dehydrogenase

Updated on 06-October-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Joel L. Sussman

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