1fgb

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[[Image:1fgb.gif|left|200px]]
 
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==TOXIN==
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The line below this paragraph, containing "STRUCTURE_1fgb", creates the "Structure Box" on the page.
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<StructureSection load='1fgb' size='340' side='right'caption='[[1fgb]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fgb]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_569B Vibrio cholerae 569B]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FGB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fgb OCA], [https://pdbe.org/1fgb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fgb RCSB], [https://www.ebi.ac.uk/pdbsum/1fgb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fgb ProSAT]</span></td></tr>
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{{STRUCTURE_1fgb| PDB=1fgb | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CHTB_VIBCH CHTB_VIBCH] The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cholera toxin, a heterohexameric AB5 enterotoxin released by Vibrio cholera, induces a profuse secretory diarrhea in susceptible hosts. Choleragenoid, the B subunit pentamer of cholera toxin, directs the enzymatic A subunit to its target by binding the GM1 gangliosides exposed on the luminal surface of intestinal epithelial cells. The crystal structure of choleragenoid has been independently solved and refined at 2.4 A resolution by combining single isomorphous replacement with non-crystallographic symmetry averaging. The structure of the B subunits, and their pentameric arrangement, closely resembles that reported for the intact holotoxin, choleragen, the heat-labile enterotoxin from Escherichia coli, and for a choleragenoid-GM1 pentasaccharide complex. In the absence of the A subunit the central cavity of the B pentamer is a highly solvated channel. The binding of choleragenoid to the A subunit or to its receptor pentasaccharide modestly affects the local stereochemistry without perceptibly altering the subunit interface.
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'''TOXIN'''
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The 2.4 A crystal structure of cholera toxin B subunit pentamer: choleragenoid.,Zhang RG, Westbrook ML, Westbrook EM, Scott DL, Otwinowski Z, Maulik PR, Reed RA, Shipley GG J Mol Biol. 1995 Aug 25;251(4):550-62. PMID:7658472<ref>PMID:7658472</ref>
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==Overview==
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Cholera toxin, a heterohexameric AB5 enterotoxin released by Vibrio cholera, induces a profuse secretory diarrhea in susceptible hosts. Choleragenoid, the B subunit pentamer of cholera toxin, directs the enzymatic A subunit to its target by binding the GM1 gangliosides exposed on the luminal surface of intestinal epithelial cells. The crystal structure of choleragenoid has been independently solved and refined at 2.4 A resolution by combining single isomorphous replacement with non-crystallographic symmetry averaging. The structure of the B subunits, and their pentameric arrangement, closely resembles that reported for the intact holotoxin, choleragen, the heat-labile enterotoxin from Escherichia coli, and for a choleragenoid-GM1 pentasaccharide complex. In the absence of the A subunit the central cavity of the B pentamer is a highly solvated channel. The binding of choleragenoid to the A subunit or to its receptor pentasaccharide modestly affects the local stereochemistry without perceptibly altering the subunit interface.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1FGB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FGB OCA].
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</div>
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<div class="pdbe-citations 1fgb" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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The 2.4 A crystal structure of cholera toxin B subunit pentamer: choleragenoid., Zhang RG, Westbrook ML, Westbrook EM, Scott DL, Otwinowski Z, Maulik PR, Reed RA, Shipley GG, J Mol Biol. 1995 Aug 25;251(4):550-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7658472 7658472]
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*[[Cholera toxin 3D structures|Cholera toxin 3D structures]]
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[[Category: Single protein]]
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*[[User:David Solfiell/sandbox 1|User:David Solfiell/sandbox 1]]
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[[Category: Vibrio cholerae]]
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== References ==
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[[Category: Westbrook, E.]]
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<references/>
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[[Category: Zhang, R G.]]
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__TOC__
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[[Category: Adp-ribosylation]]
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</StructureSection>
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[[Category: Cholera toxin]]
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[[Category: Large Structures]]
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[[Category: Choleragenoid]]
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[[Category: Vibrio cholerae 569B]]
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[[Category: Enterotoxin]]
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[[Category: Westbrook E]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:17:34 2008''
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[[Category: Zhang R-G]]

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TOXIN

PDB ID 1fgb

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