7d5z

==Crystal structure of EBV gH/gL bound with neutralizing antibody 1D8==

<StructureSection load='7d5z' size='340' side='right'caption='[[7d5z]], [[Resolution|resolution]] 4.20&Aring;' scene=''>

<table><tr><td colspan='2'>[[7d5z]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_4 Human gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D5Z FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.2&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d5z OCA], [https://pdbe.org/7d5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d5z RCSB], [https://www.ebi.ac.uk/pdbsum/7d5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d5z ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/GH_EBVG GH_EBVG] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis. The heterodimer gH/gL targets also host EPHA2 to promote viral entry.[UniProtKB:P03231][HAMAP-Rule:MF_04033]

==See Also==

*[[Antibody 3D structures|Antibody 3D structures]]

[[Category: Homo sapiens]]

[[Category: Human gammaherpesvirus 4]]

[[Category: Shan S]]

[[Category: Zhu Q]]