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3cfo

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Current revision (12:27, 30 August 2023) (edit) (undo)
 
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<StructureSection load='3cfo' size='340' side='right'caption='[[3cfo]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='3cfo' size='340' side='right'caption='[[3cfo]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3cfo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteriophage_rb69 Bacteriophage rb69]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CFO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3cfo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_RB69 Escherichia phage RB69]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CFO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GMP:GUANOSINE'>GMP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ih7|1ih7]], [[1ig9|1ig9]], [[3cfp|3cfp]], [[3cfr|3cfr]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GMP:GUANOSINE'>GMP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">43 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12353 Bacteriophage RB69])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cfo OCA], [https://pdbe.org/3cfo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cfo RCSB], [https://www.ebi.ac.uk/pdbsum/3cfo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cfo ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cfo OCA], [https://pdbe.org/3cfo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cfo RCSB], [https://www.ebi.ac.uk/pdbsum/3cfo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cfo ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/DPOL_BPR69 DPOL_BPR69]] This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction.
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[https://www.uniprot.org/uniprot/DPOL_BPR69 DPOL_BPR69] This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cfo ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cfo ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacteriophage rb69]]
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[[Category: Escherichia phage RB69]]
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Klimenko, D]]
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[[Category: Klimenko D]]
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[[Category: Konigsberg, W H]]
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[[Category: Konigsberg WH]]
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[[Category: Steitz, T A]]
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[[Category: Steitz TA]]
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[[Category: Wang, J]]
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[[Category: Wang J]]
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[[Category: Wang, M]]
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[[Category: Wang M]]
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[[Category: Apo]]
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[[Category: Base selectivity]]
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[[Category: Closed]]
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[[Category: Dna replication]]
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[[Category: Dna-binding]]
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[[Category: Dna-directed dna polymerase]]
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[[Category: Exonuclease]]
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[[Category: Half-closed]]
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[[Category: Hydrolase]]
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[[Category: Nuclease]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Open]]
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[[Category: Transferase]]
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Current revision

Triple Mutant APO structure

PDB ID 3cfo

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