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3fg1

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Current revision (06:45, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3fg1' size='340' side='right'caption='[[3fg1]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='3fg1' size='340' side='right'caption='[[3fg1]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3fg1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Black_sea_rod Black sea rod]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FG1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3fg1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plexaura_homomalla Plexaura homomalla]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FG1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fnq|2fnq]], [[3fg3|3fg3]], [[3fg4|3fg4]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Arachidonate_8-lipoxygenase Arachidonate 8-lipoxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.40 1.13.11.40] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fg1 OCA], [https://pdbe.org/3fg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fg1 RCSB], [https://www.ebi.ac.uk/pdbsum/3fg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fg1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fg1 OCA], [https://pdbe.org/3fg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fg1 RCSB], [https://www.ebi.ac.uk/pdbsum/3fg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fg1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/AOSL_PLEHO AOSL_PLEHO]] Bifunctional enzyme which is responsible for allene oxide biosynthesis via a two-step reaction which involves conversion of arachidonic acid to a 8R-hydroperoxide intermediate followed by conversion of the hydroperoxide to allene oxide.<ref>PMID:9302294</ref> <ref>PMID:10559269</ref>
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[https://www.uniprot.org/uniprot/AOSL_PLEHO AOSL_PLEHO] Bifunctional enzyme which is responsible for allene oxide biosynthesis via a two-step reaction which involves conversion of arachidonic acid to a 8R-hydroperoxide intermediate followed by conversion of the hydroperoxide to allene oxide.<ref>PMID:9302294</ref> <ref>PMID:10559269</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arachidonate 8-lipoxygenase]]
 
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[[Category: Black sea rod]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Neau, D B]]
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[[Category: Plexaura homomalla]]
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[[Category: Newcomer, M E]]
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[[Category: Neau DB]]
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[[Category: Arichidonic metabolism]]
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[[Category: Newcomer ME]]
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[[Category: Dioxygenase]]
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[[Category: Fatty acid biosynthesis]]
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[[Category: Heme]]
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[[Category: Iron]]
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[[Category: Lipid synthesis]]
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[[Category: Lipoxygenase]]
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[[Category: Lyase]]
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[[Category: Membrane]]
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[[Category: Metal-binding]]
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[[Category: Multifunctional enzyme]]
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[[Category: Oxidoreductase]]
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[[Category: Oxylipin biosynthesis]]
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Current revision

Crystal structure of Delta413-417:GS LOX

PDB ID 3fg1

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