3fia
From Proteopedia
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<StructureSection load='3fia' size='340' side='right'caption='[[3fia]], [[Resolution|resolution]] 1.45Å' scene=''> | <StructureSection load='3fia' size='340' side='right'caption='[[3fia]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3fia]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3fia]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FIA FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | < | + | |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fia OCA], [https://pdbe.org/3fia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fia RCSB], [https://www.ebi.ac.uk/pdbsum/3fia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fia ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fia OCA], [https://pdbe.org/3fia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fia RCSB], [https://www.ebi.ac.uk/pdbsum/3fia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fia ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/ITSN1_HUMAN ITSN1_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.<ref>PMID:11744688</ref> <ref>PMID:22648170</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fi/3fia_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fi/3fia_consurf.spt"</scriptWhenChecked> | ||
| - | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> |
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Acton | + | [[Category: Acton TB]] |
| - | [[Category: Chen | + | [[Category: Chen Y]] |
| - | [[Category: Ciccosanti | + | [[Category: Ciccosanti C]] |
| - | [[Category: Devices | + | [[Category: Devices C]] |
| - | [[Category: Foote | + | [[Category: Foote EL]] |
| - | [[Category: Hunt | + | [[Category: Hunt JF]] |
| - | [[Category: Mao | + | [[Category: Mao L]] |
| - | [[Category: Montelione | + | [[Category: Montelione GT]] |
| - | + | [[Category: Seetharaman J]] | |
| - | [[Category: Seetharaman | + | [[Category: Tong L]] |
| - | [[Category: Tong | + | [[Category: Vorobiev SM]] |
| - | [[Category: Vorobiev | + | [[Category: Xiao R]] |
| - | [[Category: Xiao | + | [[Category: Zhao L]] |
| - | [[Category: Zhao | + | |
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Current revision
Crystal structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646e.
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Categories: Homo sapiens | Large Structures | Acton TB | Chen Y | Ciccosanti C | Devices C | Foote EL | Hunt JF | Mao L | Montelione GT | Seetharaman J | Tong L | Vorobiev SM | Xiao R | Zhao L
