1fi2

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[[Image:1fi2.gif|left|200px]]
 
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==CRYSTAL STRUCTURE OF GERMIN (OXALATE OXIDASE)==
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The line below this paragraph, containing "STRUCTURE_1fi2", creates the "Structure Box" on the page.
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<StructureSection load='1fi2' size='340' side='right'caption='[[1fi2]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fi2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hordeum_vulgare Hordeum vulgare]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FI2 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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{{STRUCTURE_1fi2| PDB=1fi2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fi2 OCA], [https://pdbe.org/1fi2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fi2 RCSB], [https://www.ebi.ac.uk/pdbsum/1fi2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fi2 ProSAT]</span></td></tr>
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</table>
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'''CRYSTAL STRUCTURE OF GERMIN (OXALATE OXIDASE)'''
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== Function ==
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[https://www.uniprot.org/uniprot/OXO1_HORVU OXO1_HORVU] Releases hydrogen peroxide in the apoplast which may be important for cross-linking reactions in the cell wall biochemistry. May play an important role in several aspects of plant growth and defense mechanisms.
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Germin is a hydrogen peroxide generating oxalate oxidase with extreme thermal stability; it is involved in the defense against biotic and abiotic stress in plants. The structure, determined at 1.6 A resolution, comprises beta-jellyroll monomers locked into a homohexamer (a trimer of dimers), with extensive surface burial accounting for its remarkable stability. The germin dimer is structurally equivalent to the monomer of the 7S seed storage proteins (vicilins), indicating evolution from a common ancestral protein. A single manganese ion is bound per germin monomer by ligands similar to those of manganese superoxide dismutase (MnSOD). Germin is also shown to have SOD activity and we propose that the defense against extracellular superoxide radicals is an important additional role for germin and related proteins.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fi/1fi2_consurf.spt"</scriptWhenChecked>
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1FI2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hordeum_vulgare Hordeum vulgare]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FI2 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Germin is a manganese containing homohexamer with oxalate oxidase and superoxide dismutase activities., Woo EJ, Dunwell JM, Goodenough PW, Marvier AC, Pickersgill RW, Nat Struct Biol. 2000 Nov;7(11):1036-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11062559 11062559]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fi2 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Hordeum vulgare]]
[[Category: Hordeum vulgare]]
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[[Category: Oxalate oxidase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Dunwell JM]]
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[[Category: Dunwell, J M.]]
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[[Category: Goodenough PW]]
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[[Category: Goodenough, P W.]]
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[[Category: Marvier AC]]
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[[Category: Marvier, A C.]]
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[[Category: Pickersgill RW]]
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[[Category: Pickersgill, R W.]]
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[[Category: Woo EJ]]
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[[Category: Woo, E J.]]
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[[Category: Beta-jellyroll]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:21:02 2008''
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Current revision

CRYSTAL STRUCTURE OF GERMIN (OXALATE OXIDASE)

PDB ID 1fi2

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