2hu4
From Proteopedia
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<StructureSection load='2hu4' size='340' side='right'caption='[[2hu4]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='2hu4' size='340' side='right'caption='[[2hu4]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2hu4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2hu4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. The May 2009 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Influenza Neuraminidase'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2009_5 10.2210/rcsb_pdb/mom_2009_5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HU4 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G39:(3R,4R,5S)-4-(ACETYLAMINO)-5-AMINO-3-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC+ACID'>G39</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hu4 OCA], [https://pdbe.org/2hu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hu4 RCSB], [https://www.ebi.ac.uk/pdbsum/2hu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hu4 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hu4 OCA], [https://pdbe.org/2hu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hu4 RCSB], [https://www.ebi.ac.uk/pdbsum/2hu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hu4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/NRAM_I04A1 NRAM_I04A1] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.[HAMAP-Rule:MF_04071] | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Influenza A virus]] | ||
[[Category: Influenza Neuraminidase]] | [[Category: Influenza Neuraminidase]] | ||
| - | [[Category: Influenza a virus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: RCSB PDB Molecule of the Month]] | [[Category: RCSB PDB Molecule of the Month]] | ||
| - | [[Category: Blackburn | + | [[Category: Blackburn GM]] |
| - | [[Category: Collins | + | [[Category: Collins PJ]] |
| - | [[Category: Gamblin | + | [[Category: Gamblin SJ]] |
| - | [[Category: Haire | + | [[Category: Haire LF]] |
| - | [[Category: Hay | + | [[Category: Hay AJ]] |
| - | [[Category: Lin | + | [[Category: Lin YP]] |
| - | [[Category: Russell | + | [[Category: Russell RJ]] |
| - | [[Category: Skehel | + | [[Category: Skehel JJ]] |
| - | [[Category: Stevens | + | [[Category: Stevens DJ]] |
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Current revision
N1 neuraminidase in complex with oseltamivir 2
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