1osl

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==Solution structure of a dimeric lactose DNA-binding domain complexed to a nonspecific DNA sequence==
==Solution structure of a dimeric lactose DNA-binding domain complexed to a nonspecific DNA sequence==
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<StructureSection load='1osl' size='340' side='right'caption='[[1osl]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1osl' size='340' side='right'caption='[[1osl]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1osl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OSL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1osl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OSL FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1l1m|1l1m]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LACI ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1osl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1osl OCA], [https://pdbe.org/1osl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1osl RCSB], [https://www.ebi.ac.uk/pdbsum/1osl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1osl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1osl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1osl OCA], [https://pdbe.org/1osl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1osl RCSB], [https://www.ebi.ac.uk/pdbsum/1osl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1osl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/LACI_ECOLI LACI_ECOLI]] Repressor of the lactose operon. Binds allolactose as an inducer.
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[https://www.uniprot.org/uniprot/LACI_ECOLI LACI_ECOLI] Repressor of the lactose operon. Binds allolactose as an inducer.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/1osl_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/1osl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Boelens, R]]
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[[Category: Boelens R]]
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[[Category: Bonvin, A M.J J]]
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[[Category: Bonvin AMJJ]]
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[[Category: Kalodimos, C G]]
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[[Category: Kalodimos CG]]
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[[Category: Kaptein, R]]
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[[Category: Kaptein R]]
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[[Category: Lac repressor]]
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[[Category: Nonspecific interaction]]
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[[Category: Protein-dna complex]]
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[[Category: Transcription-dna complex]]
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Current revision

Solution structure of a dimeric lactose DNA-binding domain complexed to a nonspecific DNA sequence

PDB ID 1osl

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