121d

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NT:NETROPSIN'>NT</scene></td></tr>

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

The molecular structure of the complex between the minor groove binding drug netropsin and the dodecamer d(CGCAAATTTGCG) has been solved and refined by X-ray diffraction analysis to an R-factor of 19.8% and 2.2-A resolution. The drug lies in the narrow minor groove of the B-DNA fragment, covering five of the six A.T base pairs (from A5.T20 to T9.A16). The long six A.T base pair tract allows the drug to bind in a position that optimizes its contacts with the DNA, establishing hydrogen bonds with O2 of thymines and N3 of adenines. The DNA molecule shows a high propeller twist only at the A6.T19 step of the A-tract. Two three-centered hydrogen bonds are observed in the major groove at half of the A-tract.

Molecular structure of the A-tract DNA dodecamer d(CGCAAATTTGCG) complexed with the minor groove binding drug netropsin.,Tabernero L, Verdaguer N, Coll M, Fita I, van der Marel GA, van Boom JH, Rich A, Aymami J Biochemistry. 1993 Aug 24;32(33):8403-10. PMID:8395202<ref>PMID:8395202</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

</div>

<div class="pdbe-citations 121d" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Aymami, J]]

[[Category: Boom, J H.Van]]

[[Category: Coll, M]]

[[Category: Fita, I]]

[[Category: Marel, G A.Van Der]]

[[Category: Rich, A]]

[[Category: Tabernero, L]]

[[Category: Verdaguer, N]]

[[Category: B-dna]]

[[Category: Complexed with drug]]

[[Category: Double helix]]