1x7a

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1x7a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X7A FirstGlance]. <br>
<table><tr><td colspan='2'>[[1x7a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X7A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=187:1-{3-[AMINO(IMINO)METHYL]PHENYL}-N-[4-(1H-BENZIMIDAZOL-1-YL)-2-FLUOROPHENYL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXAMIDE'>187</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1pfx|1pfx]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=187:1-{3-[AMINO(IMINO)METHYL]PHENYL}-N-[4-(1H-BENZIMIDAZOL-1-YL)-2-FLUOROPHENYL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-5-CARBOXAMIDE'>187</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Coagulation_factor_IXa Coagulation factor IXa], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.22 3.4.21.22] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x7a OCA], [https://pdbe.org/1x7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x7a RCSB], [https://www.ebi.ac.uk/pdbsum/1x7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x7a ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x7a OCA], [https://pdbe.org/1x7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x7a RCSB], [https://www.ebi.ac.uk/pdbsum/1x7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x7a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/FA9_PIG FA9_PIG]] Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
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[https://www.uniprot.org/uniprot/FA9_PIG FA9_PIG] Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x7/1x7a_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x7/1x7a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Coagulation factor IXa]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Alexander, R S]]
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[[Category: Alexander RS]]
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[[Category: Barbera, F]]
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[[Category: Barbera F]]
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[[Category: Burdick, D]]
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[[Category: Burdick D]]
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[[Category: Luettgen, J M]]
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[[Category: Luettgen JM]]
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[[Category: Nakajima, S]]
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[[Category: Nakajima S]]
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[[Category: Rossi, K A]]
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[[Category: Rossi KA]]
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[[Category: Smallheer, J M]]
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[[Category: Smallheer JM]]
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[[Category: Smallwood, A M]]
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[[Category: Smallwood AM]]
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[[Category: Wang, J]]
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[[Category: Wang J]]
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[[Category: Wang, S]]
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[[Category: Wang S]]
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[[Category: Blood clotting]]
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[[Category: Hydrolase]]
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[[Category: Inhibition]]
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[[Category: X-ray structure]]
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Current revision

Porcine Factor IXa Complexed to 1-{3-[amino(imino)methyl]phenyl}-N-[4-(1H-benzimidazol-1-yl)-2-fluorophenyl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

PDB ID 1x7a

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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