Metabotropic glutamate receptor 3D structures

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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*Metabotropic glutamate receptor 1
+
*Metabotropic glutamate receptor 1; Domains – LBD 1-564; transmembrane 569-836
-
+
 
**[[7dgd]] – hMGluR1 - human – Cryo EM<br />
**[[7dgd]] – hMGluR1 - human – Cryo EM<br />
-
**[[7dge]] – hMGluR1 + nanobody – Cryo EM<br />
+
**[[7dge]] – hMGluR1 + nanobody + quisqualate – Cryo EM<br />
-
**[[3ks9]] – hMGluR1 (mutant) + antagonist<br />
+
**[[3ks9]] – hMGluR1 (mutant) + antagonist
**[[4or2]] - hMGluR1/cytochrome b526<br />
**[[4or2]] - hMGluR1/cytochrome b526<br />
-
**[[1ewt]], [[1ewv]] - rMGluR1 LBD - rat<br />
+
**[[1ewt]], [[1ewv]] - rMGluR1 LBD - rat
-
**[[1isr]], [[1ewk]] – rMGluR1 LBD + Glu<br />
+
**[[1isr]], [[1ewk]] – rMGluR1 LBD + Glu
-
**[[1iss]] - rMGluR1 LBD + antagonist<br />
+
**[[1iss]] - rMGluR1 LBD + antagonist
-
*Metabotropic glutamate receptor 2; Domains – LBD 1-564
+
* Metabotropic glutamate receptor 2
**[[7epa]] – hMGluR2 – Cryo EM<br />
**[[7epa]] – hMGluR2 – Cryo EM<br />
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**[[7mts]] – hMGluR2 in Gi complex + Glu – Cryo EM<br />
**[[7mts]] – hMGluR2 in Gi complex + Glu – Cryo EM<br />
**[[7e9g]] – hMGluR2 (mutant) in Gi complex + antagonist + scFv – Cryo EM<br />
**[[7e9g]] – hMGluR2 (mutant) in Gi complex + antagonist + scFv – Cryo EM<br />
-
**[[4xas]], [[4xaq]] – hMGluR2 LBD + agonist<br />
+
**[[4xaq]], [[4xas]] – hMGluR2 LBD + agonist<br />
-
**[[5kzq]], [[5kzn]] – hMGluR2 LBD + antagonist<br />
+
**[[5kzn]], [[5kzq]] – hMGluR2 LBD + antagonist<br />
**[[5cni]] – hMGluR2 LBD + Glu <br />
**[[5cni]] – hMGluR2 LBD + Glu <br />
**[[5cnj]] – hMGluR2 LBD + Glu analog<br />
**[[5cnj]] – hMGluR2 LBD + Glu analog<br />
-
**[[7epe]], [[7epf]] – hMGluR2 547-853 + antagonist + FMN<br />
+
**[[7epe]], [[7epf]] – hMGluR2 transmembrane domain + antagonist + FMN<br />
*Metabotropic glutamate receptor 3
*Metabotropic glutamate receptor 3
 +
**[[7wi6]], [[7wi8]], [[7wih]] – hMGluR3 – Cryo EM<br />
**[[5cnk]] – hMGluR3 LBD + Glu <br />
**[[5cnk]] – hMGluR3 LBD + Glu <br />
-
**[[3sm9]] - hMGluR3 + antagonist<br />
+
**[[3sm9]] - hMGluR3 + antagonist
 +
**[[8tqb]] – hMGluR3 + agonist – Cryo EM<br />
 +
**[[9ii2]], [[9ii3]] – hMGluR3 + beta-arrestin – Cryo EM<br />
**[[4xar]], [[6b7h]] – hMGluR3 LBD + agonist<br />
**[[4xar]], [[6b7h]] – hMGluR3 LBD + agonist<br />
**[[5cnm]] – hMGluR3 LBD + Glu analog<br />
**[[5cnm]] – hMGluR3 LBD + Glu analog<br />
-
**[[2e4u]] – rMGluR3 LBD (mutant) + Glu<br />
+
**[[2e4u]] – rMGluR3 LBD (mutant) + Glu
-
**[[2e4v]], [[2e4w]], [[2e4x]], [[2e4y]], [[2e4z]] - rMGluR3 LBD (mutant) + agonist<br />
+
**[[8tr2]] – rMGluR3 + agonist – Cryo EM<br />
 +
**[[8tr0]], [[8trd]] – rMGluR3 + antagonist – Cryo EM<br />
 +
**[[8trc]] – rMGluR3 + antagonist + modulator – Cryo EM<br />
 +
**[[2e4v]], [[2e4w]], [[2e4x]], [[2e4y]], [[2e4z]] - rMGluR3 LBD (mutant) + agonist
*Metabotropic glutamate receptor 4
*Metabotropic glutamate receptor 4
 +
**[[8jd6]] – hMGluR4 in Gi complex – Cryo EM<br />
**[[7e9h]] – hMGluR4 in Gi complex + antagonist + scFv – Cryo EM<br />
**[[7e9h]] – hMGluR4 in Gi complex + antagonist + scFv – Cryo EM<br />
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**[[6n52]] – hMGluR5 – Cryo EM<br />
**[[6n52]] – hMGluR5 – Cryo EM<br />
-
**[[7fd8]], [[7fd9]] – hMGluR5 + antagonist – Cryo EM<br />
+
**[[7fd9]] – hMGluR5 + antagonist – Cryo EM<br />
-
**[[6n51]], [[6n50]], [[6n4y]] – hMGluR5 + nanobody – Cryo EM<br />
+
**[[7fd8]], [[8x0b]], [[8x0c]], [[8x0d]], [[8x0e]], [[8x0f]], [[8x0g]], [[8x0h]] – hMGluR5 + quisqualate – Cryo EM<br />
 +
**[[8t7h]], [[8t8m]], [[8tao]] – hMGluR5 + nanobody + quisqualate – Cryo EM<br />
 +
**[[6n4y]], [[6n50]], [[6n51]], [[6njc]] – hMGluR5 + nanobody + quisqualate – Cryo EM<br />
 +
**[[8t6j]] – hMGluR5 + activator – Cryo EM<br />
**[[6n4x]] – hMGluR5 LBD<br />
**[[6n4x]] – hMGluR5 LBD<br />
 +
**[[3lmk]] – hMGluR5 LBD (mutant) + positive allosteric modulator + Glu
**[[6ffh]], [[6ffi]] - hMGluR5 LBD (mutant) + positive allosteric modulator<br />
**[[6ffh]], [[6ffi]] - hMGluR5 LBD (mutant) + positive allosteric modulator<br />
-
**[[3lmk]] – hMGluR5 LBD (mutant) + positive allosteric modulator + Glu<br />
+
**[[9hc3]] - hMGluR5 transmembrane domain/endolysin<br />
-
**[[5cgc]], [[5cgd]] - hMGluR5 transmembrane domain + negative allosteric modulator<br />
+
**[[9hc0]] - hMGluR5 transmembrane domain/endolysin + alloswitchc<br />
-
**[[7p2l]] - hMGluR5 transmembrane domain (mutant) 569-836 + negative allosteric modulator<br />
+
**[[4oo9]], [[5cgc]], [[5cgd]] - hMGluR5 transmembrane domain + negative allosteric modulator<br />
 +
**[[7p2l]] - hMGluR5 transmembrane domain (mutant) + negative allosteric modulator<br />
*Metabotropic glutamate receptor 7
*Metabotropic glutamate receptor 7
-
**[[7epc]] – hMGluR7 – Cryo EM<br />
+
**[[7epc]], [[9omo]], [[9omp]] – hMGluR7 – Cryo EM<br />
**[[5c5c]] – hMGluR7 LBD (mutant)<br />
**[[5c5c]] – hMGluR7 LBD (mutant)<br />
-
**[[3mq4]] – hMGluR7 LBD + antagonist<br />
+
**[[3mq4]] – hMGluR7 LBD + antagonist
*Metabotropic glutamate receptor 8
*Metabotropic glutamate receptor 8
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**[[6bt5]] – hMGluR8 LBD + phosphonobutanoic acid <br />
**[[6bt5]] – hMGluR8 LBD + phosphonobutanoic acid <br />
**[[6e5v]] – hMGluR8 N-terminal (mutant) + inhibitor <br />
**[[6e5v]] – hMGluR8 N-terminal (mutant) + inhibitor <br />
 +
 +
*Metabotropic glutamate receptor 2+3
 +
 +
**[[8jcu]], [[8jcv]], [[8jcw]], [[8jcx]], [[8jcy]], [[8jcz]], [[8jd0]], [[8jd1]], [[8jd2]] – hMGluR + Glu – Cryo EM<br />
 +
**[[8jd3]] – hMGluR in GI complex – Cryo EM<br />
 +
 +
*Metabotropic glutamate receptor 2+4
 +
 +
**[[8jd4]] – hMGluR – Cryo EM<br />
 +
**[[8jd5]], [[8wgb]] – hMGluR in GI complex – Cryo EM<br />
 +
**[[8wg9]], [[8wgc]] – hMGluR + agonist – Cryo EM<br />
 +
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D structures of metabotropic glutamate receptor

Updated on 16-July-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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