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7q3o
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of CDX1 bound to hydroxymethylated DNA== | |
| - | + | <StructureSection load='7q3o' size='340' side='right'caption='[[7q3o]], [[Resolution|resolution]] 2.78Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7q3o]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q3O FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.78Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5HC:2-DEOXY-5-(HYDROXYMETHYL)CYTIDINE+5-(DIHYDROGEN+PHOSPHATE)'>5HC</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q3o OCA], [https://pdbe.org/7q3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q3o RCSB], [https://www.ebi.ac.uk/pdbsum/7q3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q3o ProSAT]</span></td></tr> |
| - | [[Category: Popov | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Yin | + | [https://www.uniprot.org/uniprot/CDX1_HUMAN CDX1_HUMAN] Plays a role in transcriptional regulation (PubMed:24623306). Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306). Could play a role in the terminal differentiation of the intestine.<ref>PMID:24623306</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Morgunova E]] | ||
| + | [[Category: Popov A]] | ||
| + | [[Category: Taipale J]] | ||
| + | [[Category: Yin Y]] | ||
Current revision
Structure of CDX1 bound to hydroxymethylated DNA
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