1fm4

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[[Image:1fm4.gif|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE BIRCH POLLEN ALLERGEN BET V 1L==
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The line below this paragraph, containing "STRUCTURE_1fm4", creates the "Structure Box" on the page.
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<StructureSection load='1fm4' size='340' side='right'caption='[[1fm4]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fm4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Betula_pendula Betula pendula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FM4 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DXC:(3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC+ACID'>DXC</scene></td></tr>
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{{STRUCTURE_1fm4| PDB=1fm4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fm4 OCA], [https://pdbe.org/1fm4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fm4 RCSB], [https://www.ebi.ac.uk/pdbsum/1fm4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fm4 ProSAT]</span></td></tr>
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</table>
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'''CRYSTAL STRUCTURE OF THE BIRCH POLLEN ALLERGEN BET V 1L'''
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== Function ==
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[https://www.uniprot.org/uniprot/BEV1L_BETPN BEV1L_BETPN] May be a general steroid carrier protein.<ref>PMID:12473456</ref>
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Bet v 1l is a naturally occurring hypoallergenic isoform of the major birch pollen allergen Bet v 1. The Bet v 1 protein belongs to the ubiquitous family of pathogenesis-related plant proteins (PR-10), which are produced in defense-response to various pathogens. Although the allergenic properties of PR-10 proteins have been extensively studied, their biological function in plants is not known. The crystal structure of Bet v 1l in complex with deoxycholate has been determined to a resolution of 1.9A using the method of molecular replacement. The structure reveals a large hydrophobic Y-shaped cavity that spans the protein and is partly occupied by two deoxycholate molecules which are bound in tandem and only partially exposed to solvent. This finding indicates that the hydrophobic cavity may have a role in facilitating the transfer of apolar ligands. The structural similarity of deoxycholate and brassinosteroids (BRs) ubiquitous plant steroid hormones, prompted the mass spectrometry (MS) study in order to examine whether BRs can bind to Bet v 1l. The MS analysis of a mixture of Bet v 1l and BRs revealed a specific non-covalent interaction of Bet v 1l with brassinolide and 24-epicastasterone. Together, our findings are consistent with a general plant-steroid carrier function for Bet v 1 and related PR-10 proteins. The role of BRs transport in PR-10 proteins may be of crucial importance in the plant defense response to pathological situations as well as in growth and development.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fm/1fm4_consurf.spt"</scriptWhenChecked>
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1FM4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Betula_pendula Betula pendula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FM4 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier., Markovic-Housley Z, Degano M, Lamba D, von Roepenack-Lahaye E, Clemens S, Susani M, Ferreira F, Scheiner O, Breiteneder H, J Mol Biol. 2003 Jan 3;325(1):123-33. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12473456 12473456]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fm4 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Betula pendula]]
[[Category: Betula pendula]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Breiteneder, H.]]
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[[Category: Breiteneder H]]
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[[Category: Clemens, S.]]
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[[Category: Clemens S]]
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[[Category: Degano, M.]]
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[[Category: Degano M]]
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[[Category: Ferreira, F.]]
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[[Category: Ferreira F]]
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[[Category: Lamba, D.]]
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[[Category: Lamba D]]
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[[Category: Markovic-Housley, Z.]]
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[[Category: Markovic-Housley Z]]
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[[Category: Roepenack-Lahaye, E von.]]
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[[Category: Scheiner O]]
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[[Category: Scheiner, O.]]
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[[Category: Susani M]]
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[[Category: Susani, M.]]
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[[Category: Von Roepenack-Lahaye E]]
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[[Category: Alpha-beta: 6 anti-parallel beta strands and 3 alpha helices.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:29:30 2008''
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Current revision

CRYSTAL STRUCTURE OF THE BIRCH POLLEN ALLERGEN BET V 1L

PDB ID 1fm4

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