7c7k

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<StructureSection load='7c7k' size='340' side='right'caption='[[7c7k]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
<StructureSection load='7c7k' size='340' side='right'caption='[[7c7k]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7c7k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecobd Ecobd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C7K FirstGlance]. <br>
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C7K FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACN:ACETONE'>ACN</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=G3H:GLYCERALDEHYDE-3-PHOSPHATE'>G3H</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ECBD_2224 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=469008 ECOBD])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACN:ACETONE'>ACN</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=G3H:GLYCERALDEHYDE-3-PHOSPHATE'>G3H</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c7k OCA], [https://pdbe.org/7c7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c7k RCSB], [https://www.ebi.ac.uk/pdbsum/7c7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c7k ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c7k OCA], [https://pdbe.org/7c7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c7k RCSB], [https://www.ebi.ac.uk/pdbsum/7c7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c7k ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
 
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[[https://www.uniprot.org/uniprot/A0A140NCK4_ECOBD A0A140NCK4_ECOBD]] Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.[ARBA:ARBA00003501]
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecobd]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bao, L Y]]
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[[Category: Bao LY]]
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[[Category: Bostrom, I K]]
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[[Category: Bostrom IK]]
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[[Category: Chen, A Q]]
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[[Category: Chen AQ]]
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[[Category: Gu, S H]]
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[[Category: Gu SH]]
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[[Category: Ji, C N]]
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[[Category: Ji CN]]
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[[Category: Li, J X]]
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[[Category: Li JX]]
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[[Category: Liu, M R]]
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[[Category: Liu MR]]
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[[Category: Wang, Y D]]
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[[Category: Wang YD]]
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[[Category: Yao, Y C]]
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[[Category: Yao YC]]
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[[Category: Zhang, L]]
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[[Category: Zhang L]]
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[[Category: Ecgapdh 1]]
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[[Category: Nad]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal Structure of Thioacyl-Glyceraldehyde-3-phosphate dehydrogenase 1(GAPDH 1) from Escherichia coli at 1.77 Angstrom resolution

PDB ID 7c7k

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